MedKoo Cat#: 565177 | Name: Ac-Phe-NH2
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Ac-Phe-NH2 is a non-competitive inhibitor (Ki = 8 ± 1.2 mM) of polyubiquitin chain elongation by destabilizing the active trimer.

Chemical Structure

Ac-Phe-NH2
Ac-Phe-NH2
CAS#7376-90-1

Theoretical Analysis

MedKoo Cat#: 565177

Name: Ac-Phe-NH2

CAS#: 7376-90-1

Chemical Formula: C11H14N2O2

Exact Mass: 206.1055

Molecular Weight: 206.25

Elemental Analysis: C, 64.06; H, 6.84; N, 13.58; O, 15.51

Price and Availability

Size Price Availability Quantity
250mg USD 350.00 2 Weeks
500mg USD 600.00 2 Weeks
1g USD 950.00 2 Weeks
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Related CAS #
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Synonym
Ac Phe-NH2; Ac-Phe NH2; Ac Phe NH2; Ac-Phe-NH2
IUPAC/Chemical Name
N-Acetylphenylalanyl-amide; (S)-2-Acetamido-3-phenylpropanamide
InChi Key
LRSBEAVFLIKKIO-JTQLQIEISA-N
InChi Code
InChI=1S/C11H14N2O2/c1-8(14)13-10(11(12)15)7-9-5-3-2-4-6-9/h2-6,10H,7H2,1H3,(H2,12,15)(H,13,14)/t10-/m0/s1
SMILES Code
O=C(N)[C@H](CC1=CC=CC=C1)NC(C)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 206.25 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Silver MS, Stoddard M. Kinetic studies on the mechanism of pepsin action. Biochemistry. 1975 Feb 11;14(3):614-21. doi: 10.1021/bi00674a023. PMID: 234250. 2: Meredith D, Temple CS, Guha N, Sword CJ, Boyd CA, Collier ID, Morgan KM, Bailey PD. Modified amino acids and peptides as substrates for the intestinal peptide transporter PepT1. Eur J Biochem. 2000 Jun;267(12):3723-8. doi: 10.1046/j.1432-1327.2000.01405.x. PMID: 10848990. 3: Mitsuta Y, Asada T, Shigeta Y. Calculation of the permeability coefficients of small molecules through lipid bilayers by free-energy reaction network analysis following the explicit treatment of the internal conformation of the solute. Phys Chem Chem Phys. 2022 Nov 2;24(42):26070-26082. doi: 10.1039/d2cp03678a. PMID: 36268802. 4: Loquais Y, Gloaguen E, Alauddin M, Brenner V, Tardivel B, Mons M. On the near UV photophysics of a phenylalanine residue: conformation-dependent ππ* state deactivation revealed by laser spectroscopy of isolated neutral dipeptides. Phys Chem Chem Phys. 2014 Oct 28;16(40):22192-200. doi: 10.1039/c4cp03401e. Epub 2014 Sep 12. PMID: 25213197. 5: DeTar DF. Computation of enzyme-substrate specificity. Biochemistry. 1981 Mar 31;20(7):1730-43. doi: 10.1021/bi00510a005. PMID: 7225355.