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MedKoo Cat#: 565151 | Name: JNJ-26993135

Description:

WARNING: This product is for research use only, not for human or veterinary use.

JNJ-26993135 is a potent and selective leukotriene A4 hydrolase (LTA4H) inhibitor.

Chemical Structure

JNJ-26993135
JNJ-26993135
CAS#841202-16-2

Theoretical Analysis

MedKoo Cat#: 565151

Name: JNJ-26993135

CAS#: 841202-16-2

Chemical Formula: C20H20N2O3S

Exact Mass: 368.1195

Molecular Weight: 368.45

Elemental Analysis: C, 65.20; H, 5.47; N, 7.60; O, 13.03; S, 8.70

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
JNJ26993135; JNJ-26993135; JNJ 26993135
IUPAC/Chemical Name
1-[4-(Benzothiazol-2-yloxy)-benzyl]-piperidine-4-carboxylic acid
InChi Key
BUZBVOKDNAZIIM-UHFFFAOYSA-N
InChi Code
InChI=1S/C20H20N2O3S/c23-19(24)15-9-11-22(12-10-15)13-14-5-7-16(8-6-14)25-20-21-17-3-1-2-4-18(17)26-20/h1-8,15H,9-13H2,(H,23,24)
SMILES Code
O=C(C1CCN(CC2=CC=C(OC3=NC4=CC=CC=C4S3)C=C2)CC1)O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 368.45 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Whittle BJ, Varga C, Berko A, Horvath K, Posa A, Riley JP, Lundeen KA, Fourie AM, Dunford PJ. Attenuation of inflammation and cytokine production in rat colitis by a novel selective inhibitor of leukotriene A4 hydrolase. Br J Pharmacol. 2008 Mar;153(5):983-91. Epub 2007 Dec 24. PubMed PMID: 18157165; PubMed Central PMCID: PMC2267273. 2: Rao NL, Dunford PJ, Xue X, Jiang X, Lundeen KA, Coles F, Riley JP, Williams KN, Grice CA, Edwards JP, Karlsson L, Fourie AM. Anti-inflammatory activity of a potent, selective leukotriene A4 hydrolase inhibitor in comparison with the 5-lipoxygenase inhibitor zileuton. J Pharmacol Exp Ther. 2007 Jun;321(3):1154-60. Epub 2007 Mar 19. PubMed PMID: 17371808.