Bcl-2 inhibitor S1 | Pan-Bcl-2 Family Inhibitor

MedKoo Cat#: 565146 | Name: Bcl-2 inhibitor S1

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Bcl-2 inhibitor S1 is a pan-Bcl-2 family inhibitor which up-regulates the BH3-only protein Noxa, which inhibits Mcl-1, thereby inducing autophagy through (ER) stress and disruption of the interaction of Beclin 1 with Bcl-2.

Chemical Structure

Bcl-2 inhibitor S1

CAS#NONE

Theoretical Analysis

MedKoo Cat#: 565146

Name: Bcl-2 inhibitor S1

CAS#: NONE

Chemical Formula: C19H13N3OS

Exact Mass: 331.0779

Molecular Weight: 331.39

Elemental Analysis: C, 68.86; H, 3.95; N, 12.68; O, 4.83; S, 9.67

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

Bcl2 inhibitor S1; Bcl 2 inhibitor S1; Bcl-2 inhibitor S1

IUPAC/Chemical Name

1-Oxo-6-thiomorpholino-1H-phenalene-2,3-dicarbonitrile

InChi Key

QHLRHJLFVYIFBN-UHFFFAOYSA-N

InChi Code

InChI=1S/C19H13N3OS/c20-10-15-12-4-5-17(22-6-8-24-9-7-22)13-2-1-3-14(18(12)13)19(23)16(15)11-21/h1-5H,6-9H2

SMILES Code

N#CC(C1=O)=C(C#N)C2=C3C1=CC=CC3=C(N4CCSCC4)C=C2

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 331.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Li X, Kang Y, Jiao B, Xia M, Wu Y, Sun L. Autophagy eliminates ER membrane reorganization induced by Bcl-2 inhibitor in HeLa cells. Oncol Rep. 2016 Dec;36(6):3353-3362. doi: 10.3892/or.2016.5209. Epub 2016 Oct 27. PubMed PMID: 27805250. 2: Zhang Z, Liu Y, Song T, Xue Z, Shen X, Liang F, Zhao Y, Li Z, Sheng H. An antiapoptotic Bcl-2 family protein index predicts the response of leukaemic cells to the pan-Bcl-2 inhibitor S1. Br J Cancer. 2013 May 14;108(9):1870-8. doi: 10.1038/bjc.2013.152. Epub 2013 Apr 4. PubMed PMID: 23558901; PubMed Central PMCID: PMC3658527. 3: Zhang Z, Wu G, Gao J, Song T. Inclusion complex of a Bcl-2 inhibitor with cyclodextrin: characterization, cellular accumulation, and in vivo antitumor activity. Mol Pharm. 2010 Aug 2;7(4):1348-54. doi: 10.1021/mp100081x. PubMed PMID: 20550194.