CCG-232964 | CAS#

MedKoo Cat#: 555501 | Name: CCG-232964

Description:

WARNING: This product is for research use only, not for human or veterinary use.

CCG-232964 is a super potent inhibitor of Rho/myocardin-related transcription factor (MRTF)/serum response factor (SRF)-mediated gene transcription (SRE. L IC50 = 1.2 pM). CCG-232964 may be a Potential Antifibrotic Agent for Scleroderma. CCG-232964 significantly reduced bleomycin-induced dermal fibrosis.

Chemical Structure

CCG-232964

CAS#Unknown

Theoretical Analysis

MedKoo Cat#: 555501

Name: CCG-232964

CAS#: Unknown

Chemical Formula: C15H15ClN2O3S

Exact Mass: 338.0492

Molecular Weight: 338.81

Elemental Analysis: C, 53.18; H, 4.46; Cl, 10.46; N, 8.27; O, 14.17; S, 9.46

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

CCG-232964; CCG 232964; CCG232964;

IUPAC/Chemical Name

4-((5-(2-Chloro-4-cyclopropylphenyl)-1,3,4-oxadiazol-2-yl)thio)-butanoic Acid

InChi Key

AKQOOCVXRXDGNN-UHFFFAOYSA-N

InChi Code

InChI=1S/C15H15ClN2O3S/c16-12-8-10(9-3-4-9)5-6-11(12)14-17-18-15(21-14)22-7-1-2-13(19)20/h5-6,8-9H,1-4,7H2,(H,19,20)

SMILES Code

O=C(O)CCCSC1=NN=C(C2=CC=C(C3CC3)C=C2Cl)O1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

The development of an inhibitor that blocks the Rho/MRTF/SRF transcription pathway downstream of surface receptors, which in principle could block multiple extracellular inputs, is a promising new approach toward the treatment of SSc and other fibrotic diseases.

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 338.81 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

5-Aryl-1,3,4-oxadiazol-2-ylthioalkanoic Acids: A Highly Potent New Class of Inhibitors of Rho/Myocardin-Related Transcription Factor (MRTF)/Serum Response Factor (SRF)-Mediated Gene Transcription as Potential Antifibrotic Agents for Scleroderma Dylan J. Kahl, Kim M. Hutchings, Erika Mathes Lisabeth, Andrew J. Haak, Jeffrey R. Leipprandt, Thomas Dexheimer, Dinesh Khanna, Pei-Suen Tsou, Phillip L. Campbell, David A. Fox, Bo Wen, Duxin Sun, Marc Bailie, Richard R. Neubig, and Scott D. Larsen Publication Date (Web): April 5, 2019 (Article) DOI: 10.1021/acs.jmedchem.8b01772