Zacopride hydrochloride | CAS# 99617-34-2 | Anti-emetic

MedKoo Cat#: 573507 | Name: Zacopride hydrochloride

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Zacopride hydrochloride is a IK1/Kir2.1 channel agonist which acts as an anti-emetic and peristaltic.

Chemical Structure

Zacopride hydrochloride

CAS#99617-34-2

Theoretical Analysis

MedKoo Cat#: 573507

Name: Zacopride hydrochloride

CAS#: 99617-34-2

Chemical Formula: C15H23Cl2N3O3

Exact Mass: 363.1116

Molecular Weight: 364.27

Elemental Analysis: C, 49.46; H, 6.36; Cl, 19.46; N, 11.54; O, 13.18

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

AHR-11190-B, Zacopride hydrochloride, Zacopride HCl

IUPAC/Chemical Name

Benzamide, 4-amino-N-1-azabicyclo(2.2.2)oct-3-yl-5-chloro-2-methoxy-, monohydrochloride, monohydrate

InChi Key

NPXXKMBXEODDAF-UHFFFAOYSA-N

InChi Code

1S/C15H20ClN3O2.ClH.H2O/c1-21-14-7-12(17)11(16)6-10(14)15(20)18-13-8-19-4-2-9(13)3-5-19;;/h6-7,9,13H,2-5,8,17H2,1H3,(H,18,20);1H;1H2

SMILES Code

O.Cl.COc1cc(N)c(Cl)cc1C(=O)NC2CN3CCC2CC3

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 364.27 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Zhai XW, Zhang L, Guo YF, Yang Y, Wang DM, Zhang Y, Li P, Niu YF, Feng QL, Wu BW, Cao JM, Liu QH. The IK1/Kir2.1 channel agonist zacopride prevents and cures acute ischemic arrhythmias in the rat. PLoS One. 2017 May 18;12(5):e0177600. doi: 10.1371/journal.pone.0177600. eCollection 2017. PubMed PMID: 28542320; PubMed Central PMCID: PMC5436763. 2: Mele PC, McDonough JR, McLean DB, O'Halloran KP. Cisplatin-induced conditioned taste aversion: attenuation by dexamethasone but not zacopride or GR38032F. Eur J Pharmacol. 1992 Aug 6;218(2-3):229-36. PubMed PMID: 1330594. 3: Sancilio LF, Pinkus LM, Jackson CB, Munson HR Jr. Studies on the emetic and antiemetic properties of zacopride and its enantiomers. Eur J Pharmacol. 1991 Jan 17;192(3):365-9. PubMed PMID: 2055236.