Synonym
Salizid; Nilazid; Nupasal; Salizide; Salicylaldehyde isonicotinoyl hydrazone; SIH1; SIH-1; SIH 1; Salinazid; Salicylaldehyde Isonicotinoyl Hydrazine; NSC 33760; NSC33760; NSC-33760;
IUPAC/Chemical Name
(E)-N'-(2-hydroxybenzylidene)isonicotinohydrazide
InChi Key
VBIZUNYMJSPHBH-OQLLNIDSSA-N
InChi Code
InChI=1S/C13H11N3O2/c17-12-4-2-1-3-11(12)9-15-16-13(18)10-5-7-14-8-6-10/h1-9,17H,(H,16,18)/b15-9+
SMILES Code
O=C(N/N=C/C1=CC=CC=C1O)C2=CC=NC=C2
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
|
Solvent |
mg/mL |
mM |
| Solubility |
| DMF |
10.0 |
41.50 |
| DMF:PBS (pH 7.2) (1:3) |
0.2 |
0.95 |
| DMSO |
5.0 |
20.70 |
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.
Preparing Stock Solutions
The following data is based on the
product
molecular weight
241.25
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
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2: Konijn AM, Glickstein H, Vaisman B, Meyron-Holtz EG, Slotki IN, Cabantchik ZI. The cellular labile iron pool and intracellular ferritin in K562 cells. Blood. 1999 Sep 15;94(6):2128-34. PMID: 10477743.
3: Tsafack A, Loyevsky M, Ponka P, Cabantchik ZI. Mode of action of iron (III) chelators as antimalarials. IV. Potentiation of desferal action by benzoyl and isonicotinoyl hydrazone derivatives. J Lab Clin Med. 1996 Jun;127(6):574-82. doi: 10.1016/s0022-2143(96)90148-1. PMID: 8648262.
4: Garrick LM, Gniecko K, Hoke JE, al-Nakeeb A, Ponka P, Garrick MD. Ferric- salicylaldehyde isonicotinoyl hydrazone, a synthetic iron chelate, alleviates defective iron utilization by reticulocytes of the Belgrade rat. J Cell Physiol. 1991 Mar;146(3):460-5. doi: 10.1002/jcp.1041460317. PMID: 2022700.
5: Evans AT, Croft SL, Peters W, Neal RA. Antileishmanial effects of clofazimine and other antimycobacterial agents. Ann Trop Med Parasitol. 1989 Oct;83(5):447-54. doi: 10.1080/00034983.1989.11812371. PMID: 2619361.
6: Ponka P, Schulman HM. Acquisition of iron from transferrin regulates reticulocyte heme synthesis. J Biol Chem. 1985 Nov 25;260(27):14717-21. PMID: 4055798.
