Sufotidine is a long-acting competitive H2 receptor antagonist which was under development as an antiulcerant. It was planned to be a follow-up compound to ranitidine (Zantac). When taken in doses of 600 mg twice daily it induced virtually 24-hour gastric anacidity thus closely resembling the antisecretory effect of the proton pump inhibitor omeprazole. Its development was terminated based on the appearance of carcinoid tumors in long-term toxicity testing in rodents.
MedKoo Cat#: 573489
Name: Sufotidine
CAS#: 80343-63-1
Chemical Formula: C20H31N5O3S
Exact Mass: 421.2148
Molecular Weight: 421.56
Elemental Analysis: C, 56.98; H, 7.41; N, 16.61; O, 11.39; S, 7.61
The following data is based on the product molecular weight 421.56 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
