CM-118 is a potent and selective dual inhibitor of c-Met and ALK which potently abrogates hepatocyte growth factor (HGF)-induced c-Met phosphorylation and cell migration, as well as phosphorylation of ALK, EML4-ALK, and ALK resistance mutants in transfected cells.
MedKoo Cat#: 565091
Name: CM-118
CAS#: 1370652-56-4
Chemical Formula: C19H16Cl2FN5O3
Exact Mass: 451.0614
Molecular Weight: 452.27
Elemental Analysis: C, 50.46; H, 3.57; Cl, 15.68; F, 4.20; N, 15.49; O, 10.61
The following data is based on the product molecular weight 452.27 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
