IUPAC/Chemical Name
5-Hydroxy-4-methoxycanthin-6-one
InChi Key
PGFKZUOYIFDMQJ-UHFFFAOYSA-N
InChi Code
InChI=1S/C15H10N2O3/c1-20-14-11-12-9(6-7-16-11)8-4-2-3-5-10(8)17(12)15(19)13(14)18/h2-7,18H,1H3
SMILES Code
O=C(N1C2=C3C=CC=C2)C(O)=C(OC)C4=C1C3=CC=N4
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
266.26
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Gong G, Jiang L, Lin Q, Liu W, He MF, Zhang J, Feng F, Qu W, Xie N. In vivo toxic effects of 4-methoxy-5-hydroxy-canthin-6-one in zebrafish embryos via copper dyshomeostasis and oxidative stress. Comp Biochem Physiol C Toxicol Pharmacol. 2018 Jan;204:79-87. doi: 10.1016/j.cbpc.2017.11.014. Epub 2017 Dec 5. PubMed PMID: 29208543.
2: Liu JF, Shao M, Zhai DW, Liu K, Wu LJ. Protective effect of 4-methoxy-5-hydroxycanthin-6-one, a natural alkaloid, on dextran sulfate sodium-induced rat colitis. Planta Med. 2009 Feb;75(2):142-5. doi: 10.1055/s-0028-1088390. Epub 2008 Dec 15. PubMed PMID: 19085815.
3: Dai W, He J, Ye F, Xu J, Liu W, Feng F, Qu W. Design, synthesis and in vitro biological evaluation of novel 4-methoxy-5-hydroxycanthin-6-one derivatives as potential anti-tumor agents. Nat Prod Res. 2019 Jan 2:1-6. doi: 10.1080/14786419.2018.1536708. [Epub ahead of print] PubMed PMID: 30600699.
4: Fan H, Qi D, Yang M, Fang H, Liu K, Zhao F. In vitro and in vivo anti-inflammatory effects of 4-methoxy-5- hydroxycanthin-6-one, a natural alkaloid from Picrasma quassioides. Phytomedicine. 2013 Feb 15;20(3-4):319-23. doi: 10.1016/j.phymed.2012.11.016. Epub 2012 Dec 24. PubMed PMID: 23271002.
