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MedKoo Cat#: 565078 | Name: Fluxapyroxad
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Fluxapyroxad is a succinate dehydrogenase inhibitor (SDHI). It interferes with a number of key fungal life functions, including spore germination, germ tube growth, appresoria formation and mycelium growth. Specifically it interferes with the production of succinate dehydrogenase, the complex II in the mitochondrial respiration chain, which in turn interferes with the tricarboxylic cycle and mitochondrial electron transport.

Chemical Structure

Fluxapyroxad
Fluxapyroxad
CAS#907204-31-3

Theoretical Analysis

MedKoo Cat#: 565078

Name: Fluxapyroxad

CAS#: 907204-31-3

Chemical Formula: C18H12F5N3O

Exact Mass: 381.0901

Molecular Weight: 381.31

Elemental Analysis: C, 56.70; H, 3.17; F, 24.91; N, 11.02; O, 4.20

Price and Availability

Size Price Availability Quantity
50mg USD 250.00 2 Weeks
100mg USD 450.00 2 Weeks
200mg USD 750.00 2 Weeks
500mg USD 1,650.00 2 Weeks
1g USD 2,950.00 2 Weeks
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Related CAS #
No Data
Synonym
Fluxapyroxad; Xemium;
IUPAC/Chemical Name
3-(Difluoromethyl)-1-methyl-N-[2-(3,4,5-trifluorophenyl)phenyl]pyrazole-4-carboxamide
InChi Key
SXSGXWCSHSVPGB-UHFFFAOYSA-N
InChi Code
InChI=1S/C18H12F5N3O/c1-26-8-11(16(25-26)17(22)23)18(27)24-14-5-3-2-4-10(14)9-6-12(19)15(21)13(20)7-9/h2-8,17H,1H3,(H,24,27)
SMILES Code
O=C(C1=CN(C)N=C1C(F)F)NC2=CC=CC=C2C3=CC(F)=C(F)C(F)=C3
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 381.31 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Chen X, Qiu T, Pan M, Xiao P, Li W. Fluxapyroxad disrupt erythropoiesis in zebrafish (Danio rerio) embryos. Ecotoxicol Environ Saf. 2022 Dec 1;247:114259. doi: 10.1016/j.ecoenv.2022.114259. Epub 2022 Nov 2. PMID: 36334343. 2: Wang Y, Lu N, Wang K, Li Y, Zhang M, Liu S, Li Y, Zhou F. Fluxapyroxad Resistance Mechanisms in Sclerotinia sclerotiorum. Plant Dis. 2023 Apr;107(4):1035-1043. doi: 10.1094/PDIS-07-22-1615-RE. Epub 2023 Apr 19. PMID: 36058635. 3: Lin H, Lin F, Yuan J, Cui F, Chen J. Toxic effects and potential mechanisms of Fluxapyroxad to zebrafish (Danio rerio) embryos. Sci Total Environ. 2021 May 15;769:144519. doi: 10.1016/j.scitotenv.2020.144519. Epub 2021 Jan 12. PMID: 33482547. 4: Li W, Wu Y, Yuan M, Liu X. Fluxapyroxad induces developmental delay in zebrafish (Danio rerio). Chemosphere. 2020 Oct;256:127037. doi: 10.1016/j.chemosphere.2020.127037. Epub 2020 May 13. PMID: 32434089. 5: Gao P, Zeng R, Gao S, Xu L, Song Z, Dai F. Resistance Profiles of Botrytis cinerea to Fluxapyroxad from Strawberry Fields in Shanghai, China. Plant Dis. 2023 Sep;107(9):2724-2728. doi: 10.1094/PDIS-10-22-2416-RE. Epub 2023 Sep 20. PMID: 36825320. 6: Mao X, Wu Z, Zhao F, Yang X, Zhou M, Hou YP. Bioactivity and Resistance Risk of a Novel SDHI fungicide fluxapyroxad in Didymella bryoniae. Plant Dis. 2023 Sep 29. doi: 10.1094/PDIS-07-23-1374-RE. Epub ahead of print. PMID: 37773329. 7: Cui K, Guan S, Liang J, Fang L, Ding R, Wang J, Li T, Dong Z, Wu X, Zheng Y. Dissipation, metabolism, accumulation, processing and risk assessment of fluxapyroxad in cucumber and cowpea vegetables from field to table. Food Chem. 2023 Oct 15;423:136384. doi: 10.1016/j.foodchem.2023.136384. Epub 2023 May 13. PMID: 37201257. 8: Yu H, Zhang J, Chen Y, Chen J, Qiu Y, Zhao Y, Li H, Xia S, Chen S, Zhu J. The adverse effects of fluxapyroxad on the neurodevelopment of zebrafish embryos. Chemosphere. 2022 Nov;307(Pt 1):135751. doi: 10.1016/j.chemosphere.2022.135751. Epub 2022 Jul 18. PMID: 35863420. 9: Li W, Guo S, Miao N. Transcriptional responses of fluxapyroxad-induced dysfunctional heart in zebrafish (Danio rerio) embryos. Environ Sci Pollut Res Int. 2022 Dec;29(60):90034-90045. doi: 10.1007/s11356-022-21981-6. Epub 2022 Jul 21. PMID: 35864390. 10: Ceballos-Alcantarilla E , López-Puertollano D , Agulló C , Abad-Fuentes A , Abad-Somovilla A , Mercader JV . Combined heterologies for monoclonal antibody- based immunoanalysis of fluxapyroxad. Analyst. 2018 Nov 19;143(23):5718-5727. doi: 10.1039/c8an01771a. PMID: 30378598. 11: Wang X, Chen L, Ren X, Kang S, Li W, Chen Z. A Nationwide Study of Residual Fate of Fluxapyroxad and Its Metabolites in Peanut Crops Across China: Assessment of Human Exposure Potential. Molecules. 2022 Dec 26;28(1):194. doi: 10.3390/molecules28010194. PMID: 36615390; PMCID: PMC9822388. 12: Qiu T, Chen X, Xiao P, Wang L, Li W. Effects of embryonic exposure to fluxapyroxad on zebrafish (Danio rerio) ocular development. Pestic Biochem Physiol. 2022 Feb;181:105018. doi: 10.1016/j.pestbp.2021.105018. Epub 2021 Dec 22. PMID: 35082041. 13: Mercader JV, Abad-Somovilla A, Agulló C, Abad-Fuentes A. Fluxapyroxad Haptens and Antibodies for Highly Sensitive Immunoanalysis of Food Samples. J Agric Food Chem. 2017 Oct 25;65(42):9333-9341. doi: 10.1021/acs.jafc.7b03199. Epub 2017 Oct 12. PMID: 28974098. 14: Islam T, Vera C, Slaski J, Mohr R, Rashid KY, Booker H, Kutcher HR. Fungicide Management of Pasmo Disease of Flax and Sensitivity of Septoria linicola to Pyraclostrobin and Fluxapyroxad. Plant Dis. 2021 Jun;105(6):1677-1684. doi: 10.1094/PDIS-06-20-1175-RE. Epub 2021 May 5. PMID: 33206013. 15: Noh HH, Lee JY, Park HK, Lee JW, Jo SH, Lim JB, Shin HG, Kwon H, Kyung KS. Dissipation, persistence, and risk assessment of fluxapyroxad and penthiopyrad residues in perilla leaf (Perilla frutescens var. japonica Hara). PLoS One. 2019 Apr 9;14(4):e0212209. doi: 10.1371/journal.pone.0212209. PMID: 30964876; PMCID: PMC6456207. 16: Amiri A, Heath SM, Peres NA. Resistance to Fluopyram, Fluxapyroxad, and Penthiopyrad in Botrytis cinerea from Strawberry. Plant Dis. 2014 Apr;98(4):532-539. doi: 10.1094/PDIS-07-13-0753-RE. PMID: 30708725. 17: Zhao Y, Jiao F, Tang T, Wu S, Wang F, Zhao X. Adverse effects and potential mechanisms of fluxapyroxad in Xenopus laevis on carbohydrate and lipid metabolism. Environ Pollut. 2023 Sep 1;332:121710. doi: 10.1016/j.envpol.2023.121710. Epub 2023 May 1. PMID: 37137408. 18: Fernández-Ortuño D, Pérez-García A, Chamorro M, de la Peña E, de Vicente A, Torés JA. Resistance to the SDHI Fungicides Boscalid, Fluopyram, Fluxapyroxad, and Penthiopyrad in Botrytis cinerea from Commercial Strawberry Fields in Spain. Plant Dis. 2017 Jul;101(7):1306-1313. doi: 10.1094/PDIS-01-17-0067-RE. Epub 2017 May 24. PMID: 30682955. 19: Li S, Liu X, Chen C, Dong F, Xu J, Zheng Y. Degradation of Fluxapyroxad in Soils and Water/Sediment Systems Under Aerobic or Anaerobic Conditions. Bull Environ Contam Toxicol. 2015 Jul;95(1):45-50. doi: 10.1007/s00128-015-1556-y. Epub 2015 May 3. PMID: 25935333. 20: Wang N, Wang Y, Sun A, Zhang Z, Shi X. Accumulation and elimination properties and comparative toxicity of fluxapyroxad in juvenile and adult large yellow croaker (Larimichthys crocea). Sci Total Environ. 2024 Feb 20;912:168979. doi: 10.1016/j.scitotenv.2023.168979. Epub 2023 Nov 28. PMID: 38036135.

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