MedKoo Cat#: 565072 | Name: LEM-14
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

LEM-14 is a specific NSD2 inhibitor.

Chemical Structure

LEM-14
LEM-14
CAS#1814881-70-3

Theoretical Analysis

MedKoo Cat#: 565072

Name: LEM-14

CAS#: 1814881-70-3

Chemical Formula: C25H26N4O4S

Exact Mass: 478.1675

Molecular Weight: 478.57

Elemental Analysis: C, 62.74; H, 5.48; N, 11.71; O, 13.37; S, 6.70

Price and Availability

Size Price Availability Quantity
50mg USD 750.00 2 Weeks
100mg USD 1,250.00 2 Weeks
1g USD 4,250.00 2 Weeks
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Related CAS #
No Data
Synonym
LEM14; LEM 14; LEM-14
IUPAC/Chemical Name
(R)-2-((4-(1-Oxoisochromane-3-carbonyl)piperazin-1-yl)methyl)-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one
InChi Key
ZJOXWRFJOUWUKX-GOSISDBHSA-N
InChi Code
InChI=1S/C25H26N4O4S/c30-22-21-17-7-3-4-8-19(17)34-23(21)27-20(26-22)14-28-9-11-29(12-10-28)24(31)18-13-15-5-1-2-6-16(15)25(32)33-18/h1-2,5-6,18H,3-4,7-14H2,(H,26,27,30)/t18-/m1/s1
SMILES Code
O=C1C(C2=C(CCCC2)S3)=C3N=C(CN4CCN(C([C@@H](CC5=C6C=CC=C5)OC6=O)=O)CC4)N1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 478.57 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Shen Y, Morishita M, Lee D, Kim S, Lee T, Mevius DEHF, Roh Y, di Luccio E. Identification of LEM-14 inhibitor of the oncoprotein NSD2. Biochem Biophys Res Commun. 2019 Jan 1;508(1):102-108. doi: 10.1016/j.bbrc.2018.11.037. Epub 2018 Nov 22. PubMed PMID: 30471851.