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MedKoo Cat#: 565059 | Name: LH-708

Description:

WARNING: This product is for research use only, not for human or veterinary use.

LH-708 is an inhibitor of cystine stone formation for treatment of cystinuria.

Chemical Structure

LH-708
LH-708
CAS#1616757-93-7

Theoretical Analysis

MedKoo Cat#: 565059

Name: LH-708

CAS#: 1616757-93-7

Chemical Formula: C16H36Cl4N6O2S2

Exact Mass:

Molecular Weight: 550.42

Elemental Analysis: C, 34.91; H, 6.59; Cl, 25.76; N, 15.27; O, 5.81; S, 11.65

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
LH708; LH 708; LH-708
IUPAC/Chemical Name
(2R,2'R)-3,3'-disulfanediylbis(2-amino-1-(4-methylpiperazin-1-yl)propan-1-one) tetrahydrochloride
InChi Key
YPXJOPDHFCBKAH-UEZRWYIOSA-N
InChi Code
InChI=1S/C16H32N6O2S2.4ClH/c1-19-3-7-21(8-4-19)15(23)13(17)11-25-26-12-14(18)16(24)22-9-5-20(2)6-10-22;;;;/h13-14H,3-12,17-18H2,1-2H3;4*1H/t13-,14-;;;;/m0..../s1
SMILES Code
CN1CCN(C([C@@H](N)CSSC[C@@H](C(N2CCN(C)CC2)=O)N)=O)CC1.Cl.Cl.Cl.Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 550.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Yang Y, Albanyan H, Lee S, Aloysius H, Liang JJ, Kholodovych V, Sahota A, Hu L. Design, synthesis, and evaluation of l-cystine diamides as l-cystine crystallization inhibitors for cystinuria. Bioorg Med Chem Lett. 2018 May 1;28(8):1303-1308. doi: 10.1016/j.bmcl.2018.03.024. Epub 2018 Mar 10. PubMed PMID: 29571572; PubMed Central PMCID: PMC5893393.