MedKoo Cat#: 573476 | Name: AGN-191129
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

AGN-191129, also known as Prostaglandin F2α alcohol methyl ether (PGF2α-OMe), is an analog of PGF2α in which the C-1 carboxyl group has been replaced by an O-methyl ether. The compound is reported to retain ocular hypotensive properties, but the receptors which mediate this activity have not been clearly documented.

Chemical Structure

AGN-191129
CAS#143656-18-2

Theoretical Analysis

MedKoo Cat#: 573476

Name: AGN-191129

CAS#: 143656-18-2

Chemical Formula: C21H38O4

Exact Mass: 354.2770

Molecular Weight: 354.53

Elemental Analysis: C, 71.14; H, 10.80; O, 18.05

Price and Availability

Size Price Availability Quantity
1mg USD 250.00 2 Weeks
5mg USD 650.00 2 Weeks
10mg USD 950.00 2 Weeks
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Related CAS #
No Data
Synonym
AGN-191129, AGN191129, AGN 191129, Prostaglandin F2α alcohol methyl ether, PGF2α-OMe, UNII-NK1168QB5T
IUPAC/Chemical Name
Prosta-5,13-diene-9,11,15-triol, 1-methoxy-, (5Z,9alpha,11alpha,13E,15S)-
InChi Key
VWEVSUSNDAHANL-GPPPFWBLSA-N
InChi Code
1S/C21H38O4/c1-3-4-8-11-17(22)13-14-19-18(20(23)16-21(19)24)12-9-6-5-7-10-15-25-2/h6,9,13-14,17-24H,3-5,7-8,10-12,15-16H2,1-2H3/b9-6-,14-13+/t17-,18+,19+,20-,21+/m0/s1
SMILES Code
CCCCC[C@@H](/C=C/[C@H]1[C@@H](C[C@@H]([C@@H]1C/C=C\CCCCOC)O)O)O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 354.53 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Woodward, D.F., and Chan, M.F. Preparation of PGF-1 alcohols as ocular hypotensives 38204, 1-12 (1993). 2. Woodward, D.F., Krauss, A.H.P., Chen, J., et al. Replacement of the carboxylic acid group of prostaglandin F2α with a hydroxyl or methoxy substituent provides biologically unique compounds British Journal of Pharmacology 130, 1933-1943 (2000).