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MedKoo Cat#: 573471 | Name: Aglepristone

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Aglepristone is a synthetic steroidal antiprogestogen related to mifepristone. It is specifically used as an abortifacient in pregnant animals. Aglepristone also possesses some antiglucocorticoid activity.

Chemical Structure

Aglepristone
Aglepristone
CAS#124478-60-0

Theoretical Analysis

MedKoo Cat#: 573471

Name: Aglepristone

CAS#: 124478-60-0

Chemical Formula: C29H37NO2

Exact Mass: 431.2800

Molecular Weight: 431.62

Elemental Analysis: C, 80.70; H, 8.64; N, 3.25; O, 7.41

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Aglepristone
IUPAC/Chemical Name
11beta-(p-(Dimethylamino)phenyl)-17beta-hydroxy-17-((Z)-propenyl)estra-4,9-dien-3-one
InChi Key
RTCKAOKDXNYXEH-FWSJOHTJSA-N
InChi Code
1S/C29H37NO2/c1-5-15-29(32)16-14-26-24-12-8-20-17-22(31)11-13-23(20)27(24)25(18-28(26,29)2)19-6-9-21(10-7-19)30(3)4/h5-7,9-10,15,17,24-26,32H,8,11-14,16,18H2,1-4H3/b15-5-/t24-,25+,26-,28-,29-/m0/s1
SMILES Code
C/C=C\[C@@]1(CC[C@@H]2[C@@]1(C[C@@H](C3=C4CCC(=O)C=C4CC[C@@H]23)c5ccc(cc5)N(C)C)C)O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 431.62 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: García Mitacek MC, Bonaura MC, Praderio RG, Nuñez Favre R, de la Sota RL, Stornelli MA. Progesterone and ultrasonographic changes during aglepristone or cloprosternol treatment in queens at 21 to 22 or 35 to 38 days of pregnancy. Theriogenology. 2017 Jan 15;88:106-117. doi: 10.1016/j.theriogenology.2016.09.050. Epub 2016 Oct 6. PubMed PMID: 27865408. 2: Özalp RG, Yavuz A, Orman A, Seker I, Udum Küçükşen D, Rişvanlı A, Demiral ÖO, Wehrend A. Parturition induction in ewes by a progesterone receptor blocker, aglepristone, and subsequent neonatal survival: Preliminary results. Theriogenology. 2017 Jan 1;87:141-147. doi: 10.1016/j.theriogenology.2016.08.016. Epub 2016 Aug 22. PubMed PMID: 27658744. 3: Guil-Luna S, Millán Y, De Andres J, Rollón E, Domingo V, García-Macías J, Sánchez-Céspedes R, Martín de Las Mulas J. Prognostic impact of neoadjuvant aglepristone treatment in clinicopathological parameters of progesterone receptor-positive canine mammary carcinomas. Vet Comp Oncol. 2017 Jun;15(2):391-399. doi: 10.1111/vco.12175. Epub 2016 Jan 19. PubMed PMID: 26781329. 4: Gogny A, Fiéni F. Aglepristone: A review on its clinical use in animals. Theriogenology. 2016 Mar 1;85(4):555-66. doi: 10.1016/j.theriogenology.2015.10.010. Epub 2015 Oct 23. Review. PubMed PMID: 26525399. 5: Guil-Luna S, Stenvang J, Brünner N, De Andrés FJ, Rollón E, Domingo V, Sánchez-Céspedes R, Millán Y, Martín de Las Mulas J. Progesterone receptor isoform A may regulate the effects of neoadjuvant aglepristone in canine mammary carcinoma. BMC Vet Res. 2014 Dec 17;10:296. doi: 10.1186/s12917-014-0296-2. PubMed PMID: 25515784; PubMed Central PMCID: PMC4280049. 6: Kaya D, Küçükaslan I, Ağaoğlu AR, Ay SS, Schäfer-Somi S, Emre B, Bal Y, Einspanier A, Gürcan IS, Gültiken N, Aslan S. The effects of aglepristone alone and in combination with cloprostenol on hormonal values during termination of mid-term pregnancy in bitches. Anim Reprod Sci. 2014 May;146(3-4):210-7. doi: 10.1016/j.anireprosci.2014.03.002. Epub 2014 Mar 22. PubMed PMID: 24703776. 7: Parillo F, Dall'Aglio C, Brecchia G, Maranesi M, Polisca A, Boiti C, Zerani M. Aglepristone (RU534) effects on luteal function of pseudopregnant rabbits: steroid receptors, enzymatic activities, and hormone productions in corpus luteum and uterus. Anim Reprod Sci. 2013 Apr;138(1-2):118-32. doi: 10.1016/j.anireprosci.2013.02.001. Epub 2013 Feb 16. PubMed PMID: 23517855.