Synonym
TCMDC-124587; TCMDC 124587; TCMDC124587;
IUPAC/Chemical Name
3-ethyl-8-[(2-hydroxy-4-methoxyphenyl)methyl]-1-(3-methylbutyl)-1,3,8-triazaspiro[4.5]decane-2,4-dione
InChi Key
WYWFEKNOCLSNES-UHFFFAOYSA-N
InChi Code
InChI=1S/C22H33N3O4/c1-5-24-20(27)22(25(21(24)28)11-8-16(2)3)9-12-23(13-10-22)15-17-6-7-18(29-4)14-19(17)26/h6-7,14,16,26H,5,8-13,15H2,1-4H3
SMILES Code
O=C(N1CC)N(CCC(C)C)C2(CCN(CC3=CC=C(OC)C=C3O)CC2)C1=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
403.52
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Meyers MJ, Anderson EJ, McNitt SA, Krenning TM, Singh M, Xu J, Zeng W, Qin L,
Xu W, Zhao S, Qin L, Eickhoff CS, Oliva J, Campbell MA, Arnett SD, Prinsen MJ,
Griggs DW, Ruminski PG, Goldberg DE, Ding K, Liu X, Tu Z, Tortorella MD, Sverdrup
FM, Chen X. Evaluation of spiropiperidine hydantoins as a novel class of
antimalarial agents. Bioorg Med Chem. 2015 Aug 15;23(16):5144-50. doi:
10.1016/j.bmc.2015.02.050. Epub 2015 Mar 4. PubMed PMID: 25797165; PubMed Central
PMCID: PMC4550221.
