CWHM-1008 is a potent and orally active Antimalarial Agent. CWHM-1008 has EC50 values of 46 and 21 nM against drug-sensitive Plasmodium falciparum 3D7 and drug-resistant Dd2 strains, respectively. Furthermore, CWHM-1008 has a long half-life in mice (4.4 h) and is orally efficacious in a mouse model of malaria (qd; ED99 ∼ 30 mg/kg/day).
MedKoo Cat#: 555472
Name: CWHM-1008
CAS#: Unknown
Chemical Formula: C22H26F3N3O
Exact Mass: 405.2028
Molecular Weight: 405.47
Elemental Analysis: C, 65.17; H, 6.46; F, 14.06; N, 10.36; O, 3.95
The following data is based on the product molecular weight 405.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
