Synonym
Nifuroquine; Quinaldofur
IUPAC/Chemical Name
4-(5-Nitro-2-furyl)quinaldic acid 1-oxide
InChi Key
HOWCLZBHAPFFAN-UHFFFAOYSA-N
InChi Code
InChI=1S/C14H8N2O6/c17-14(18)11-7-9(12-5-6-13(22-12)16(20)21)8-3-1-2-4-10(8)15(11)19/h1-7H,(H,17,18)
SMILES Code
O=C(O)C1=CC(C2=CC=C([N+]([O-])=O)O2)=C3C=CC=CC3=[N+]1[O-]
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
300.23
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Tyczyñska B, Bassalik-Chabielska L. The influence of penicillin and quinaldofur on the growth of Staphylococcus epidermidis and Streptococcus faecalis in milk. Acta Microbiol Pol. 1987;36(4):309-16. PubMed PMID: 2457295.
2: Ziv G, Saran A. Quinaldofur--a new synthetic drug for the treatment of mastitis. II. Pharmacology, residues, udder irritation and clinical efficacy. Zentralbl Veterinarmed B. 1976 May;23(4):310-9. PubMed PMID: 936833.
3: Ziv G, Saran A, Schoenberger E. Quinaldofur--a new synthetic drug for the treatment of mastitis. I. In vitro characteristics. Zentralbl Veterinarmed B. 1976 May;23(4):301-9. PubMed PMID: 936832.
4: ter Laak EA, Noordergraaf JH, Verschure MH. Susceptibilities of Mycoplasma bovis, Mycoplasma dispar, and Ureaplasma diversum strains to antimicrobial agents in vitro. Antimicrob Agents Chemother. 1993 Feb;37(2):317-21. PubMed PMID: 8452363; PubMed Central PMCID: PMC187660.
5: Yan HX, Wu HP, Ashton C, Tong C, Ying QL. Rats deficient for p53 are susceptible to spontaneous and carcinogen-induced tumorigenesis. Carcinogenesis. 2012 Oct;33(10):2001-5. doi: 10.1093/carcin/bgs238. Epub 2012 Jul 12. PubMed PMID: 22791818; PubMed Central PMCID: PMC3499043.
6: Bassalik-Chabielska L, Królikowska K, Małuszyńska GM, Niedzielska A, Tyczyńska B. Growth inhibition of staphylococci and streptococci in raw milk. Acta Microbiol Pol. 1983;32(3):305-10. PubMed PMID: 6198883.
7: Hartman EG, Grootenhuis G, Werdler ME. [Mycoplasma bovis mastitis in a dairy herd in the Netherlands (author's transl)]. Tijdschr Diergeneeskd. 1981 Jan 1;106(1):3-8. Dutch. PubMed PMID: 7466765.
8: Ziv G. Availability and usage of new antibacterial drugs in Europe. J Am Vet Med Assoc. 1980 May 15;176(10 Spec No):1122-8. PubMed PMID: 7216885.
9: Groothuis DG, Frik JF. [Comparison of the sensitivity patterns of Staphylococci isolated from bovine udders in 1974 and 1980]. Tijdschr Diergeneeskd. 1982 Dec 1;107(23):883-8. Dutch. PubMed PMID: 7157324.
10: Berchtold M, Hug F, Müller R. [Effect of therapeutic factors on the treatment results in subclinical Staphylococcus mastitis]. Berl Munch Tierarztl Wochenschr. 1983 Jun 1;96(6):186-8. German. PubMed PMID: 6882350.
