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MedKoo Cat#: 584842 | Name: Nesosteine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Nesosteine is a mucoregulatory agent.

Chemical Structure

Nesosteine
Nesosteine
CAS#84233-61-4

Theoretical Analysis

MedKoo Cat#: 584842

Name: Nesosteine

CAS#: 84233-61-4

Chemical Formula: C11H11NO3S

Exact Mass: 237.0460

Molecular Weight: 237.27

Elemental Analysis: C, 55.68; H, 4.67; N, 5.90; O, 20.23; S, 13.51

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Nesosteine
IUPAC/Chemical Name
o-(3-Thiazolidinylcarbonyl)benzoic acid
InChi Key
XVAYJUBRRZOANH-UHFFFAOYSA-N
InChi Code
InChI=1S/C11H11NO3S/c13-10(12-5-6-16-7-12)8-3-1-2-4-9(8)11(14)15/h1-4H,5-7H2,(H,14,15)
SMILES Code
O=C(O)C1=CC=CC=C1C(N2CSCC2)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 237.27 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Franchi-Micheli S, Luzzi S, Ciuffi M, Gori A, Castiglioni C, Zilletti L. Effects of nesosteine on Herxheimer microshock in guinea-pigs. Agents Actions. 1987 Apr;20(3-4):327-9. PubMed PMID: 2440286. 2: Braga PC, Bossi R, Castiglioni CL, Romandini S, Allegra L. Preliminary data on the action of nesosteine, a mucomodifying drug, on mucociliary transport. J Int Med Res. 1987 Jan-Feb;15(1):57-61. PubMed PMID: 3817282. 3: Scuri R, Mondani P, Frova C, Fantini L. Nesosteine: a new mucoregulatory agent. Drugs Exp Clin Res. 1986;12(8):663-70. PubMed PMID: 3757762. 4: Braga PC, Beghi G, Castelli C, Grasselli G, Ornaghi A, Rampoldi C, Zheng Y, Allegra L. Rheological profile of nesosteine: a new mucoactive agent. Int J Clin Pharmacol Res. 1989;9(1):77-83. PubMed PMID: 2707929. 5: Gatto PG, Gramolini C, Valenti S. [Effectiveness and tolerance of a new molecule with secreto-dynamic activity: nesosteine]. Clin Ter. 1989 Jan 31;128(2):87-97. Italian. PubMed PMID: 2523778. 6: Luini W, Sozzani S, D'Alessandro F, Zhang HX, Spreafico F. Stimulation of natural host defence mechanisms in rodents by nesosteine. Int J Immunopharmacol. 1988;10(1):59-65. PubMed PMID: 3366510. 7: Girometta MA, Loschi L, Ventura P. High-performance liquid chromatographic assay of nesosteine in human plasma and urine. J Chromatogr. 1989 Jan 27;487(1):117-24. PubMed PMID: 2715254. 8: Mbuyamba P. Clinical trial with CO-1177: a preliminary report. Int J Clin Pharmacol Res. 1986;6(2):119-21. PubMed PMID: 3522442.