MedKoo Cat#: 565013 | Name: SH-2251

Description:

WARNING: This product is for research use only, not for human or veterinary use.

SH-2251 is a selective inhibitor of the generation of IL-5-producing Th2 cells and induction of active histone modifications at the IL5 gene locus during Th2 cell differentiation.

Chemical Structure

SH-2251
SH-2251
CAS#NONE

Theoretical Analysis

MedKoo Cat#: 565013

Name: SH-2251

CAS#: NONE

Chemical Formula: C19H9ClF5N3O3S

Exact Mass: 488.9973

Molecular Weight: 489.80

Elemental Analysis: C, 46.59; H, 1.85; Cl, 7.24; F, 19.39; N, 8.58; O, 9.80; S, 6.55

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
SH2251; SH 2251; SH-2251
IUPAC/Chemical Name
N-[4-(3-Chloro-5-trifluoromethyl-pyridin-2-yloxy)-2-fluoro-phenyl]-2-fluoro-5-nitro-thiobenzamide
InChi Key
BDBRUPRPLSPCOX-UHFFFAOYSA-N
InChi Code
InChI=1S/C19H9ClF5N3O3S/c20-13-5-9(19(23,24)25)8-26-17(13)31-11-2-4-16(15(22)7-11)27-18(32)12-6-10(28(29)30)1-3-14(12)21/h1-8H,(H,27,32)
SMILES Code
S=C(NC1=CC=C(OC2=NC=C(C(F)(F)F)C=C2Cl)C=C1F)C3=CC([N+]([O-])=O)=CC=C3F
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 489.80 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Suzuki J, Kuwahara M, Tofukuji S, Imamura M, Kato F, Nakayama T, Ohara O, Yamashita M. A novel small compound SH-2251 suppresses Th2 cell-dependent airway inflammation through selective modulation of chromatin status at the Il5 gene locus. PLoS One. 2013 Apr 16;8(4):e61785. doi: 10.1371/journal.pone.0061785. Print 2013. PubMed PMID: 23613936; PubMed Central PMCID: PMC3628909.