Synonym
CA-5f; CA 5f; CA5f;
IUPAC/Chemical Name
(3E,5E)-3-(3,4-dimethoxybenzylidene)-5-[(1H-indol-3-yl)methylene]-1-methylpiperidin-4-one
InChi Key
JYOLPDWVAMBMQN-UBIAKTOFSA-N
InChi Code
InChI=1S/C24H24N2O3/c1-26-14-18(10-16-8-9-22(28-2)23(11-16)29-3)24(27)19(15-26)12-17-13-25-21-7-5-4-6-20(17)21/h4-13,25H,14-15H2,1-3H3/b18-10+,19-12+
SMILES Code
O=C1/C(CN(C)C/C1=C\C2=CNC3=C2C=CC=C3)=C/C4=CC=C(OC)C(OC)=C4
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
388.47
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Kim M, Moon A. A curcumin analog CA-5f inhibits urokinase-type plasminogen
activator and invasive phenotype of triple-negative breast cancer cells. Toxicol
Res. 2021 Nov 17;38(1):19-26. doi: 10.1007/s43188-021-00112-2. PMID: 35070937;
PMCID: PMC8748588.
2: Zhang L, Qiang P, Yu J, Miao Y, Chen Z, Qu J, Zhao Q, Chen Z, Liu Y, Yao X,
Liu B, Cui L, Jing H, Sun G. Identification of compound CA-5f as a novel late-
stage autophagy inhibitor with potent anti-tumor effect against non-small cell
lung cancer. Autophagy. 2019 Mar;15(3):391-406. doi:
10.1080/15548627.2018.1511503. Epub 2018 Sep 6. PMID: 30145925; PMCID:
PMC6351124.
3: Schanne FA, Dowd TL, Gupta RK, Rosen JF. Development of 19F NMR for
measurement of [Ca2+]i and [Pb2+]i in cultured osteoblastic bone cells. Environ
Health Perspect. 1990 Mar;84:99-106. doi: 10.1289/ehp.908499. PMID: 2112459;
PMCID: PMC1567646.
