NVP-QAB205 | CAS# 325165-07-9 | Syk Inhibitor

MedKoo Cat#: 564991 | Name: NVP-QAB205

Description:

WARNING: This product is for research use only, not for human or veterinary use.

NVP-QAB205 is a Syk inhibitor.

Chemical Structure

NVP-QAB205

CAS#325165-07-9

Theoretical Analysis

MedKoo Cat#: 564991

Name: NVP-QAB205

CAS#: 325165-07-9

Chemical Formula: C18H22ClN7O

Exact Mass:

Molecular Weight: 387.87

Elemental Analysis: C, 55.74; H, 5.72; Cl, 9.14; N, 25.28; O, 4.12

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

NVPQAB205; NVP QAB205; NVP-QAB205; QAB205; QAB-205; QAB 205; NVP-QAB-205-AA

IUPAC/Chemical Name

N-[4-[6-(Cyclobutylamino)-9H-purin-2-ylamino]phenyl]-N-methylacetamide Hydrochloride

InChi Key

PVPGAZQKUBODQL-UHFFFAOYSA-N

InChi Code

InChI=1S/C18H21N7O.ClH/c1-11(26)25(2)14-8-6-13(7-9-14)22-18-23-16-15(19-10-20-16)17(24-18)21-12-4-3-5-12;/h6-10,12H,3-5H2,1-2H3,(H3,19,20,21,22,23,24);1H

SMILES Code

CC(N(C1=CC=C(NC2=NC(NC3CCC3)=C4N=CNC4=N2)C=C1)C)=O.[H]Cl

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 387.87 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: MacGlashan D Jr. Marked differences in the signaling requirements for expression of CD203c and CD11b versus CD63 expression and histamine release in human basophils. Int Arch Allergy Immunol. 2012;159(3):243-52. doi: 10.1159/000332150. Epub 2012 Jun 20. PubMed PMID: 22722613; PubMed Central PMCID: PMC3533433. 2: Patou J, Holtappels G, Affleck K, van Cauwenberge P, Bachert C. Syk-kinase inhibition prevents mast cell activation in nasal polyps. Rhinology. 2011 Mar;49(1):100-6. doi: 10.4193/Rhino09.147. PubMed PMID: 21468383. 3: Havard S, Scola AM, Kay LJ, Ishmael SS, MacGlashan DW Jr, Peachell PT. Characterization of syk expression in human lung mast cells: relationship with function. Clin Exp Allergy. 2011 Mar;41(3):378-88. doi: 10.1111/j.1365-2222.2010.03667.x. Epub 2011 Jan 24. PubMed PMID: 21255137. 4: MacGlashan D Jr, Undem BJ. Inducing an anergic state in mast cells and basophils without secretion. J Allergy Clin Immunol. 2008 Jun;121(6):1500-6, 1506.e1-4. doi: 10.1016/j.jaci.2008.04.019. PubMed PMID: 18539198.