GK187 | CAS#1071001-50-7

MedKoo Cat#: 555455 | Name: GK187

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

GK187 is a potent and selective polyfluoroalkyl ketone inhibitors of GVIA calcium-independent phospholipase A2.

Chemical Structure

GK187

CAS#1071001-50-7

Theoretical Analysis

MedKoo Cat#: 555455

Name: GK187

CAS#: 1071001-50-7

Chemical Formula: C14H15F5O2

Exact Mass: 310.0992

Molecular Weight: 310.26

Elemental Analysis: C, 54.20; H, 4.87; F, 30.62; O, 10.31

Price and Availability

Size	Price	Availability	Quantity
5mg	USD 450.00	2 Weeks
10mg	USD 850.00	2 Weeks

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Related CAS #

No Data

Synonym

GK187; GK-187; GK 187;

IUPAC/Chemical Name

1,1,1,2,2-Pentafluoro-7-(4-methoxyphenyl)heptan-3-one

InChi Key

CICDFDPOGZQTQB-UHFFFAOYSA-N

InChi Code

InChI=1S/C14H15F5O2/c1-21-11-8-6-10(7-9-11)4-2-3-5-12(20)13(15,16)14(17,18)19/h6-9H,2-5H2,1H3

SMILES Code

O=C(CCCCC1=CC=C(OC)C=C1)C(F)(F)C(F)(F)F

Appearance

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Product Data

Product Data

Instruction

View handling instruction

Biological target:

GK187 is a potent and selective Group VIA calcium-independent phospholipase A2 (GVIA iPLA2) inhibitor with an XI(50) value of 0.0001.

In vitro activity:

Especially, compound 6d (GK187) is the most potent, but also the most selective iPLA2 inhibitor presented, since it shows less that 25% inhibition against GIVA cPLA2 and 32.8% against GV sPLA2 at 0.091 mol fraction. Reference: Bioorg Med Chem. 2013 Sep 15;21(18):5823-9. https://pubmed.ncbi.nlm.nih.gov/23916152/

In vivo activity:

TBD

	Solvent	mg/mL	mM
Solubility
	DMF	10.0	32.23
	DMSO	30.0	96.69
	Ethanol	10.0	32.23
	Ethanol:PBS (pH 7.2) (1:2)	0.3	0.97

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 310.26 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

1. Magrioti V, Nikolaou A, Smyrniotou A, Shah I, Constantinou-Kokotou V, Dennis EA, Kokotos G. New potent and selective polyfluoroalkyl ketone inhibitors of GVIA calcium-independent phospholipase A2. Bioorg Med Chem. 2013 Sep 15;21(18):5823-9. doi: 10.1016/j.bmc.2013.07.010. Epub 2013 Jul 16. PMID: 23916152; PMCID: PMC3883354.

In vitro protocol:

In vivo protocol:

TBD

1: Magrioti V, Nikolaou A, Smyrniotou A, Shah I, Constantinou-Kokotou V, Dennis EA, Kokotos G. New potent and selective polyfluoroalkyl ketone inhibitors of GVIA calcium-independent phospholipase A2. Bioorg Med Chem. 2013 Sep 15;21(18):5823-9. doi: 10.1016/j.bmc.2013.07.010. Epub 2013 Jul 16. PubMed PMID: 23916152; PubMed Central PMCID: PMC3883354.