Synonym
FKGK18; FKGK-18; FKGK 18;
IUPAC/Chemical Name
1,1,1-Trifluoro-6-(2-naphthalenyl)-2-hexanone
InChi Key
VCWWTQMRNJSJGC-UHFFFAOYSA-N
InChi Code
InChI=1S/C16H15F3O/c17-16(18,19)15(20)8-4-1-5-12-9-10-13-6-2-3-7-14(13)11-12/h2-3,6-7,9-11H,1,4-5,8H2
SMILES Code
O=C(CCCCC1=CC=C2C=CC=CC2=C1)C(F)(F)F
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
280.29
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Bone RN, Gai Y, Magrioti V, Kokotou MG, Ali T, Lei X, Tse HM, Kokotos G,
Ramanadham S. Inhibition of Ca2+-independent phospholipase A2β (iPLA2β)
ameliorates islet infiltration and incidence of diabetes in NOD mice. Diabetes.
2015 Feb;64(2):541-54. doi: 10.2337/db14-0097. Epub 2014 Sep 11. PubMed PMID:
25213337; PubMed Central PMCID: PMC4303959.
2: Ali T, Kokotos G, Magrioti V, Bone RN, Mobley JA, Hancock W, Ramanadham S.
Characterization of FKGK18 as inhibitor of group VIA Ca2+-independent
phospholipase A2 (iPLA2β): candidate drug for preventing beta-cell apoptosis and
diabetes. PLoS One. 2013 Aug 20;8(8):e71748. doi: 10.1371/journal.pone.0071748.
eCollection 2013. PubMed PMID: 23977134; PubMed Central PMCID: PMC3748103.
3: Kokotos G, Hsu YH, Burke JE, Baskakis C, Kokotos CG, Magrioti V, Dennis EA.
Potent and selective fluoroketone inhibitors of group VIA calcium-independent
phospholipase A2. J Med Chem. 2010 May 13;53(9):3602-10. doi: 10.1021/jm901872v.
PubMed PMID: 20369880; PubMed Central PMCID: PMC2865582.
