Isocombretastatin A4 | CAS# 1067880-31-2 | Antiproliferative

MedKoo Cat#: 564984 | Name: Isocombretastatin A4

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Isocombretastatin A4 is an antiproliferative inhibitor of tubulin polymerization.

Chemical Structure

Isocombretastatin A4

CAS#1067880-31-2

Theoretical Analysis

MedKoo Cat#: 564984

Name: Isocombretastatin A4

CAS#: 1067880-31-2

Chemical Formula: C18H20O5

Exact Mass: 316.1311

Molecular Weight: 316.35

Elemental Analysis: C, 68.34; H, 6.37; O, 25.29

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

Isocombretastatin A4; Isocombretastatin A-4; Isocombretastatin A 4; isoCA-4

IUPAC/Chemical Name

2-Methoxy-5-[1-(3,4,5-trimethoxyphenyl)ethenyl]-phenol

InChi Key

CNGKIRSNRQSORA-UHFFFAOYSA-N

InChi Code

InChI=1S/C18H20O5/c1-11(12-6-7-15(20-2)14(19)8-12)13-9-16(21-3)18(23-5)17(10-13)22-4/h6-10,19H,1H2,2-5H3

SMILES Code

OC1=CC(C(C2=CC(OC)=C(OC)C(OC)=C2)=C)=CC=C1OC

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 316.35 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Naret T, Khelifi I, Provot O, Bignon J, Levaique H, Dubois J, Souce M, Kasselouri A, Deroussent A, Paci A, Varela PF, Gigant B, Alami M, Hamze A. 1,1-Diheterocyclic Ethylenes Derived from Quinaldine and Carbazole as New Tubulin-Polymerization Inhibitors: Synthesis, Metabolism, and Biological Evaluation. J Med Chem. 2019 Feb 28;62(4):1902-1916. doi: 10.1021/acs.jmedchem.8b01386. Epub 2018 Dec 21. PubMed PMID: 30525602. 2: Ganapathy D, Sekar G. Efficient synthesis of polysubstituted olefins using stable palladium nanocatalyst: applications in synthesis of tamoxifen and isocombretastatin A4. Org Lett. 2014 Aug 1;16(15):3856-9. doi: 10.1021/ol5017367. Epub 2014 Jul 18. PubMed PMID: 25036297.