MedKoo Cat#: 564974 | Name: CS1
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

CS1 is a potent inhibitor of microtubule polymerization via interaction with the colchicine-binding pocket of tubulin, inducing unique histone phosphorylation patterns distinct from those induced by colchicine. CS1 is an antimitotic.

Chemical Structure

CS1
CS1
CAS#1448009-94-6

Theoretical Analysis

MedKoo Cat#: 564974

Name: CS1

CAS#: 1448009-94-6

Chemical Formula: C16H12O3

Exact Mass: 252.0786

Molecular Weight: 252.27

Elemental Analysis: C, 76.18; H, 4.79; O, 19.03

Price and Availability

Size Price Availability Quantity
10mg USD 350.00 2 Weeks
50mg USD 1,050.00 2 Weeks
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Related CAS #
No Data
Synonym
CS-1; CS 1; CS1
IUPAC/Chemical Name
4-(6-Hydroxynaphthalen-2-yl)benzene-1,2-diol
InChi Key
LDFFDYWHCCDSBO-UHFFFAOYSA-N
InChi Code
InChI=1S/C16H12O3/c17-14-5-3-11-7-10(1-2-12(11)8-14)13-4-6-15(18)16(19)9-13/h1-9,17-19H
SMILES Code
OC1=CC=C(C2=CC=C3C=C(O)C=CC3=C2)C=C1O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 252.27 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Wu X, Li Z, Shen Y. The small molecule CS1 inhibits mitosis and sister chromatid resolution in HeLa cells. Biochim Biophys Acta Gen Subj. 2018 May;1862(5):1134-1147. doi: 10.1016/j.bbagen.2018.01.012. Epub 2018 Feb 15. PubMed PMID: 29410075.