NSC-2805 is a WWP2 ubiquitin ligase inhibitor. NSC-2805 effectively inhibits WWP2-mediated ubiquitination, leading to the stabilization of its target proteins. It has been shown to modulate pathways associated with cancer progression, fibrosis, and other diseases where WWP2 plays a pathogenic role. In cellular assays, NSC-2805 demonstrates dose-dependent inhibition of WWP2 activity, resulting in increased levels of tumor suppressor proteins and reduced oncogenic signaling. Some studies also suggest potential anti-proliferative effects in cancer cell lines, highlighting its therapeutic relevance.
MedKoo Cat#: 564961
Name: NSC-2805
CAS#: 4371-34-0
Chemical Formula: C14H14O4
Exact Mass: 246.0892
Molecular Weight: 246.26
Elemental Analysis: C, 68.28; H, 5.73; O, 25.99
The following data is based on the product molecular weight 246.26 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
