Azthreonam monosodium salt | CAS# 80581-85-7 | Synthetic Monobactam

MedKoo Cat#: 573371 | Name: Azthreonam monosodium salt

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Azthreonam monosodium salt is a synthetic monobactam specifically active against aerobic gram-negative bacteria.

Chemical Structure

Azthreonam monosodium salt

CAS#80581-85-7

Theoretical Analysis

MedKoo Cat#: 573371

Name: Azthreonam monosodium salt

CAS#: 80581-85-7

Chemical Formula: C13H16N5NaO8S2

Exact Mass: 457.0338

Molecular Weight: 457.41

Elemental Analysis: C, 34.14; H, 3.53; N, 15.31; Na, 5.03; O, 27.98; S, 14.02

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

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Synonym

Azthreonam monosodium salt

IUPAC/Chemical Name

Propanoic acid, 2-(((Z)-(1-(2-amino-4-thiazolyl)-2-(((2S,3S)-2-methyl-4-oxo-1-sulfo-3-azetidinyl)amino)-2-oxoethylidene)amino)oxy)-2-methyl-, monosodium salt

InChi Key

JYXMUHAHBZXBHA-QRFIBWQLSA-M

InChi Code

1S/C13H17N5O8S2.Na/c1-5-7(10(20)18(5)28(23,24)25)16-9(19)8(6-4-27-12(14)15-6)17-26-13(2,3)11(21)22;/h4-5,7H,1-3H3,(H2,14,15)(H,16,19)(H,21,22)(H,23,24,25);/q;+1/p-1/b17-8-;/t5-,7-;/m0./s1

SMILES Code

[Na+].C(C(C)(C)O\N=C(/C(=O)N[C@H]1[C@@H](N(C1=O)S(=O)(=O)O)C)c1nc(sc1)N)(=O)[O-]

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 457.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Davido B, Dinh A, Senard O, Calin R, Makhloufi S, Salomon J. Repurposing an old drug: aztreonam as a new treatment strategy for gonorrhoea. J Antimicrob Chemother. 2017 May 1;72(5):1466-1468. doi: 10.1093/jac/dkw589. PubMed PMID: 28137938. 2: Bush K, Freudenberger JS, Sykes RB. Interaction of azthreonam and related monobactams with beta-lactamases from gram-negative bacteria. Antimicrob Agents Chemother. 1982 Sep;22(3):414-20. PubMed PMID: 6982680; PubMed Central PMCID: PMC183759. 3: Sykes RB, Bonner DP, Bush K, Georgopapadakou NH. Azthreonam (SQ 26,776), a synthetic monobactam specifically active against aerobic gram-negative bacteria. Antimicrob Agents Chemother. 1982 Jan;21(1):85-92. PubMed PMID: 6979307; PubMed Central PMCID: PMC181833.