MedKoo Cat#: 564908 | Name: Govaniadine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Govaniadine is a natural potent inducer of apoptosis in MCF-7 cell lines.

Chemical Structure

Govaniadine
Govaniadine
CAS#NONE

Theoretical Analysis

MedKoo Cat#: 564908

Name: Govaniadine

CAS#: NONE

Chemical Formula: C19H19NO4

Exact Mass: 325.1314

Molecular Weight: 325.36

Elemental Analysis: C, 70.14; H, 5.89; N, 4.31; O, 19.67

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Govaniadine
IUPAC/Chemical Name
(S)-2-Methoxy-5,8,14,14a-tetrahydro-6H-[1,3]dioxolo[4,5-g]isoquinolino[2,1-b]isoquinolin-1-ol
InChi Key
VSCSJMRNBGGEEP-AWEZNQCLSA-N
InChi Code
InChI=1S/C19H19NO4/c1-22-15-3-2-11-4-5-20-9-13-8-17-16(23-10-24-17)7-12(13)6-14(20)18(11)19(15)21/h2-3,7-8,14,21H,4-6,9-10H2,1H3/t14-/m0/s1
SMILES Code
OC1=C(OC)C=CC2=C1[C@@]3([H])N(CC2)CC4=CC(OCO5)=C5C=C4C3
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 325.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Horst B, Wanner MJ, Jorgensen SI, Hiemstra H, van Maarseveen JH. Total Synthesis of the Ortho-Hydroxylated Protoberberines (S)-Govaniadine, (S)-Caseamine and (S)-Clarkeanidine via a Solvent-directed Pictet-Spengler reaction. J Org Chem. 2018 Nov 19. doi: 10.1021/acs.joc.8b02378. [Epub ahead of print] PubMed PMID: 30451502; PubMed Central PMCID: PMC6328280. 2: Sivakumaran N, Samarakoon SR, Adhikari A, Ediriweera MK, Tennekoon KH, Malavige N, Thabrew I, Shrestha RLS. Cytotoxic and Apoptotic Effects of Govaniadine Isolated from Corydalis govaniana Wall. Roots on Human Breast Cancer (MCF-7) Cells. Biomed Res Int. 2018 Jul 24;2018:3171348. doi: 10.1155/2018/3171348. eCollection 2018. PubMed PMID: 30140694; PubMed Central PMCID: PMC6081593. 3: Marques LMM, Callejon DR, Pinto LG, de Campos ML, de Oliveira ARM, Vessecchi R, Adhikari A, Shrestha RLS, Peccinini RG, Lopes NP. Pharmacokinetic properties, in vitro metabolism and plasma protein binding of govaniadine an alkaloid isolated from Corydalis govaniana Wall. J Pharm Biomed Anal. 2016 Nov 30;131:464-472. doi: 10.1016/j.jpba.2016.09.003. Epub 2016 Sep 3. PubMed PMID: 27686399. 4: Muhammad N, Shrestha RL, Adhikari A, Wadood A, Khan H, Khan AZ, Maione F, Mascolo N, De Feo V. First evidence of the analgesic activity of govaniadine, an alkaloid isolated from Corydalis govaniana Wall. Nat Prod Res. 2015;29(5):430-7. doi: 10.1080/14786419.2014.951933. Epub 2014 Aug 26. PubMed PMID: 25154594.