Platonin | CAS#3571-88-8 | dye

MedKoo Cat#: 584805 | Name: Platonin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Platonin is a therapeutic immunomodulating medicine and a possible medicine against ischemic stroke.

Chemical Structure

Platonin

CAS#3571-88-8

Theoretical Analysis

MedKoo Cat#: 584805

Name: Platonin

CAS#: 3571-88-8

Chemical Formula: C38H61I2N3S3

Exact Mass: 909.2117

Molecular Weight: 909.92

Elemental Analysis: C, 50.16; H, 6.76; I, 27.89; N, 4.62; S, 10.57

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

Platonin; NK 19

IUPAC/Chemical Name

2,2'-(3-((3-Heptyl-4-methyl-2(3H)-thiazolylidene)ethylidene)-1-propene-1,3-diyl)bis(3-heptyl-4-methylthiazolium)diiodide

InChi Key

BHSBKKSKODCAAS-UHFFFAOYSA-L

InChi Code

InChI=1S/C38H61N3S3.2HI/c1-7-10-13-16-19-26-39-32(4)29-42-36(39)24-22-35(38-41(34(6)31-44-38)28-21-18-15-12-9-3)23-25-37-40(33(5)30-43-37)27-20-17-14-11-8-2;;/h22-25,29-31H,7-21,26-28H2,1-6H3;2*1H/q+2;;/p-2

SMILES Code

CC1=CS/C(N1CCCCCCC)=C/C=C(C2=[N+](CCCCCCC)C(C)=CS2)/C=C/C3=[N+](CCCCCCC)C(C)=CS3.[I-].[I-]

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 909.92 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Yeh CT, Kao MC, Chen CH, Huang CJ. Platonin preserves blood-brain barrier integrity in septic rats. Acta Anaesthesiol Taiwan. 2015 Mar;53(1):12-5. doi: 10.1016/j.aat.2015.02.001. Epub 2015 Mar 17. PubMed PMID: 25791838. 2: Peng TC, Chang CY, Huang IT, Kao MC, Chang YY, Huang CJ. Platonin mitigates vascular hyporeactivity of thoracic aorta in septic rats. J Surg Res. 2018 Jan;221:190-195. doi: 10.1016/j.jss.2017.08.054. Epub 2017 Sep 26. PubMed PMID: 29229127. 3: Sheu JR, Chen ZC, Jayakumar T, Chou DS, Yen TL, Lee HN, Pan SH, Hsia CH, Yang CH, Hsieh CY. A novel indication of platonin, a therapeutic immunomodulating medicine, on neuroprotection against ischemic stroke in mice. Sci Rep. 2017 Feb 6;7:42277. doi: 10.1038/srep42277. PubMed PMID: 28165057; PubMed Central PMCID: PMC5292718. 4: Lee JJ, Chang CF, Sheu JR, Jayakumar T. Pharmacology and Clinical Effect of Platonin, a Cyanine Photosensitizing Dye: Potential Molecular Targets. Curr Pharm Biotechnol. 2014;15(8):700-11. PubMed PMID: 26050653. 5: Chang Y, Uen YH, Chen CC, Lin SC, Tseng SY, Wang YH, Sheu JR, Hsieh CY. Platonin inhibited PDGF-BB-induced proliferation of rat vascular smooth muscle cells via JNK1/2-dependent signaling. Acta Pharmacol Sin. 2011 Nov;32(11):1337-44. doi: 10.1038/aps.2011.105. Epub 2011 Sep 5. PubMed PMID: 21892199; PubMed Central PMCID: PMC4002726. 6: Hsu KY, Chen CH, Shih PC, Huang CJ. Adverse effects of bilateral lower limb ischemia-reperfusion on inducing kidney injuries in rats could be ameliorated by platonin. Acta Anaesthesiol Taiwan. 2012 Jun;50(2):63-8. doi: 10.1016/j.aat.2012.05.010. Epub 2012 Jun 26. PubMed PMID: 22769860. 7: Chen CC, Lee JJ, Tsai PS, Lu YT, Huang CL, Huang CJ. Platonin attenuates LPS-induced CAT-2 and CAT-2B induction in stimulated murine macrophages. Acta Anaesthesiol Scand. 2006 May;50(5):604-12. Erratum in: Acta Anaesthesiol Scand. 2007 Feb;51(2):269. PubMed PMID: 16643232. 8: Tsai CC, Lin MT, Yang CC, Liao JF, Lee JJ. Platonin, a cyanine photosensitizing dye, is effective for attenuation of heatstroke in rats. Shock. 2006 Dec;26(6):601-7. PubMed PMID: 17117136. 9: Shao DZ, Lin M. Platonin inhibits LPS-induced NF-kappaB by preventing activation of Akt and IKKbeta in human PBMC. Inflamm Res. 2008 Dec;57(12):601-6. doi: 10.1007/s00011-008-8053-2. PubMed PMID: 19109741. 10: Lee JJ, Lin MT, Wang NL, Lin CL, Chang CK. Platonin, a cyanine photosensitizing dye, causes attenuation of circulatory shock, hypercoagulable state, and tissue ischemia during heat stroke. Shock. 2005 Dec;24(6):577-82. PubMed PMID: 16317390. 11: Hsiao G, Lee JJ, Chou DS, Fong TH, Shen MY, Lin CH, Sheu JR. Platonin, a photosensitizing dye, improves circulatory failure and mortality in rat models of endotoxemia. Biol Pharm Bull. 2002 Aug;25(8):995-9. PubMed PMID: 12186433. 12: Yen TL, Chang CC, Chung CL, Ko WC, Yang CH, Hsieh CY. Neuroprotective Effects of Platonin, a Therapeutic Immunomodulating Medicine, on Traumatic Brain Injury in Mice after Controlled Cortical Impact. Int J Mol Sci. 2018 Apr 6;19(4). pii: E1100. doi: 10.3390/ijms19041100. PubMed PMID: 29642394; PubMed Central PMCID: PMC5979356. 13: Lee JJ, Liu CL, Tsai PS, Yang CL, Lao HC, Huang CJ. Platonin inhibits endotoxin-induced MAPK and AP-1 up-regulation. J Surg Res. 2011 May 15;167(2):e299-305. doi: 10.1016/j.jss.2009.11.738. Epub 2009 Dec 22. PubMed PMID: 20338586. 14: Ishihara M, Kadoma Y, Fujisawa S. Kinetic radical-scavenging activity of platonin, a cyanine photosensitizing dye. In Vivo. 2006 Nov-Dec;20(6B):845-8. PubMed PMID: 17203777. 15: Chu HN, Tsai PS, Wang TY, Huang CJ. Platonin mitigates acute lung injury in haemorrhagic shock rats. Resuscitation. 2011 Jan;82(1):97-104. doi: 10.1016/j.resuscitation.2010.08.036. Epub 2010 Oct 6. Erratum in: Resuscitation. 2013 Mar;84(3):397-8. PubMed PMID: 20932630. 16: Chen YJ, Huang WP, Yang YC, Lin CP, Chen SH, Hsu ML, Tseng YJ, Shieh HR, Chen YY, Lee JJ. Platonin induces autophagy-associated cell death in human leukemia cells. Autophagy. 2009 Feb;5(2):173-83. Epub 2009 Feb 6. PubMed PMID: 19066447. 17: Hsu KY, Tsai PS, Lee JJ, Wang TY, Huang CJ. Platonin mitigates acute lung injury induced by bilateral lower limb ischemia-reperfusion in rats. J Surg Res. 2011 May 15;167(2):e255-62. doi: 10.1016/j.jss.2010.03.075. Epub 2010 Apr 24. Erratum in: J Surg Res. 2014 Apr;187(2):e7. PubMed PMID: 20472255. 18: Chen KB, Lee CY, Lee JJ, Tsai PS, Huang CJ. Platonin mitigates lung injury in a two-hit model of hemorrhage/resuscitation and endotoxemia in rats. J Trauma Acute Care Surg. 2012 Mar;72(3):660-70. doi: 10.1097/TA.0b013e3182318551. PubMed PMID: 22491550. 19: Nakagawa Y, Homma S, Yamamoto I, Banno M, Nakazato H, Imanaga H, Yamamoto N. In vivo and in vitro activation of macrophages with a cyanine photosensitizing dye, platonin. Cancer Immunol Immunother. 1993 Aug;37(3):157-62. PubMed PMID: 8392911. 20: Yamamoto I, Morishita K. Development of enzyme immunoassay for Platonin (NK 19). J Immunoassay. 1986;7(1-2):17-35. PubMed PMID: 3525611.