JWG-115 | BET Selective Inhibitor

MedKoo Cat#: 564881 | Name: JWG-115

Description:

WARNING: This product is for research use only, not for human or veterinary use.

JWG-115 is a BET selective inhibitor which targets BRD4.

Chemical Structure

JWG-115

CAS#NONE

Theoretical Analysis

MedKoo Cat#: 564881

Name: JWG-115

CAS#: NONE

Chemical Formula: C38H49N7O3

Exact Mass: 651.3897

Molecular Weight: 651.86

Elemental Analysis: C, 70.02; H, 7.58; N, 15.04; O, 7.36

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

JWG115; JWG 115; JWG-115

IUPAC/Chemical Name

11-Cyclopentyl-2-((2-isopropoxy-4-(4-(4-methylpiperazin-1-yl)piperidine-1-carbonyl)phenyl)amino)-5-methyl-5,11-dihydro-6H-benzo[e]pyrido[3,2-b][1,4]diazepin-6-one

InChi Key

XEULWIQXBPFNGA-UHFFFAOYSA-N

InChi Code

InChI=1S/C38H49N7O3/c1-26(2)48-34-25-27(37(46)44-19-17-28(18-20-44)43-23-21-41(3)22-24-43)13-14-31(34)39-35-16-15-33-36(40-35)45(29-9-5-6-10-29)32-12-8-7-11-30(32)38(47)42(33)4/h7-8,11-16,25-26,28-29H,5-6,9-10,17-24H2,1-4H3,(H,39,40)

SMILES Code

O=C1C2=CC=CC=C2N(C3CCCC3)C4=NC(NC5=CC=C(C(N6CCC(N7CCN(C)CC7)CC6)=O)C=C5OC(C)C)=CC=C4N1C

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 651.86 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Wang J, Erazo T, Ferguson FM, Buckley DL, Gomez N, Muñoz-Guardiola P, Diéguez-Martínez N, Deng X, Hao M, Massefski W, Fedorov O, Offei-Addo NK, Park PM, Dai L, DiBona A, Becht K, Kim ND, McKeown MR, Roberts JM, Zhang J, Sim T, Alessi DR, Bradner JE, Lizcano JM, Blacklow SC, Qi J, Xu X, Gray NS. Structural and Atropisomeric Factors Governing the Selectivity of Pyrimido-benzodiazipinones as Inhibitors of Kinases and Bromodomains. ACS Chem Biol. 2018 Sep 21;13(9):2438-2448. doi: 10.1021/acschembio.7b00638. Epub 2018 Aug 31. PubMed PMID: 30102854; PubMed Central PMCID: PMC6333101.