MedKoo Cat#: 531372 | Name: PF-04753299
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

PF-04753299 is a potent and selective inhibitor of LpxC (UDP-3-O-(R-3-hydroxymyristol)-N-acetylglucosamine deacetylase) that is effective in a murine of gram-negative bacteria infection model.

Chemical Structure

PF-04753299
CAS#1289620-49-0

Theoretical Analysis

MedKoo Cat#: 531372

Name: PF-04753299

CAS#: 1289620-49-0

Chemical Formula: C18H21NO4S

Exact Mass: 347.1191

Molecular Weight: 347.43

Elemental Analysis: C, 62.23; H, 6.09; N, 4.03; O, 18.42; S, 9.23

Price and Availability

Size Price Availability Quantity
5mg USD 500.00
25mg USD 925.00 2 Weeks
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Related CAS #
No Data
Synonym
PF-04753299
IUPAC/Chemical Name
(2R)-4-Biphenyl-4-yl-N-hydroxy-2-methyl-2-(methylsulfonyl)butanamide
InChi Key
GDYIQUFNICPYHF-GOSISDBHSA-N
InChi Code
InChI=1S/C18H21NO4S/c1-18(17(20)19-21,24(2,22)23)13-12-14-8-10-16(11-9-14)15-6-4-3-5-7-15/h3-11,21H,12-13H2,1-2H3,(H,19,20)/t18-/m1/s1
SMILES Code
O=C(NO)[C@@](S(=O)(C)=O)(C)CCC1=CC=C(C2=CC=CC=C2)C=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Biological target:
PF-04753299 is a potent and selective UDP-3-O-(R-3-hydroxymyristol)-N-acetylglucosamine deacetylase (LpxC) inhibitor.
In vitro activity:
TBD
In vivo activity:
TBD

Preparing Stock Solutions

The following data is based on the product molecular weight 347.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
TBD
In vitro protocol:
TBD
In vivo protocol:
TBD
Hogan AM, Motnenko A, Rahman ASMZ, Cardona ST. Cell envelope structural and functional contributions to antibiotic resistance in Burkholderia cenocepacia. J Bacteriol. 2024 Apr 18;206(4):e0044123. doi: 10.1128/jb.00441-23. Epub 2024 Mar 19. PMID: 38501654; PMCID: PMC11025338.