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MedKoo Cat#: 531367 | Name: PF-05236216 hydrochloride
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

PF-05236216 hydrochloride is a brain penetrant, potent and selective inhibitor of casein kinase 1 delta/epsilon (CK1δ/ε) that modulates circadian rhythms in mice.

Chemical Structure

PF-05236216 hydrochloride
CAS#1383376-93-9

Theoretical Analysis

MedKoo Cat#: 531367

Name: PF-05236216 hydrochloride

CAS#: 1383376-93-9

Chemical Formula: C18H16ClFN4O

Exact Mass: 358.0997

Molecular Weight: 358.80

Elemental Analysis: C, 60.26; H, 4.49; Cl, 9.88; F, 5.29; N, 15.62; O, 4.46

Price and Availability

Size Price Availability Quantity
5mg USD 450.00
25mg USD 900.00 2 Weeks
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Related CAS #
No Data
Synonym
PF-05236216 hydrochloride; PF05236216 hydrochloride; PF 05236216 hydrochloride; PF-05236216 HCl; PF05236216 HCl;
IUPAC/Chemical Name
4-[3-(4-Fluorophenyl)-1-methyl-1H-pyrazol-4-yl]-6,7-dihydro-6-methyl-5H-pyrrolo[3,4-b]pyridin-5-one hydrochloride
InChi Key
CLDJMFXSCFWXDI-UHFFFAOYSA-N
InChi Code
InChI=1S/C18H15FN4O.ClH/c1-22-10-15-16(18(22)24)13(7-8-20-15)14-9-23(2)21-17(14)11-3-5-12(19)6-4-11;/h3-9H,10H2,1-2H3;1H
SMILES Code
O=C1N(C)CC2=NC=CC(C3=CN(C)N=C3C4=CC=C(F)C=C4)=C21.[H]Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
PF-05236216 hydrochloride is a brain penetrant, potent and selective inhibitor of casein kinase 1 delta/epsilon (CK1δ/ε).
In vitro activity:
TBD
In vivo activity:
TBD

Preparing Stock Solutions

The following data is based on the product molecular weight 358.80 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
TBD
In vitro protocol:
TBD
In vivo protocol:
TBD