MedKoo Cat#: 531338 | Name: PF-06748962
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

PF-06748962 is a potent and selective lactam-based prostaglandin EP3 receptor antagonist.

Chemical Structure

PF-06748962
PF-06748962
CAS#1952261-87-8

Theoretical Analysis

MedKoo Cat#: 531338

Name: PF-06748962

CAS#: 1952261-87-8

Chemical Formula: C21H21N3O2

Exact Mass: 347.1634

Molecular Weight: 347.42

Elemental Analysis: C, 72.60; H, 6.09; N, 12.10; O, 9.21

Price and Availability

Size Price Availability Quantity
5mg USD 450.00
25mg USD 900.00
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Related CAS #
No Data
Synonym
PF-06748962
IUPAC/Chemical Name
3-[(3R)-3-Methyl-2-oxo-3-piperidinyl]-6-(5-methyl-3-quinolinyl)-2(1H)-pyridinone
InChi Key
OJVNYQOKTZLPPX-OAQYLSRUSA-N
InChi Code
InChI=1S/C21H21N3O2/c1-13-5-3-6-18-15(13)11-14(12-23-18)17-8-7-16(19(25)24-17)21(2)9-4-10-22-20(21)26/h3,5-8,11-12H,4,9-10H2,1-2H3,(H,22,26)(H,24,25)/t21-/m1/s1
SMILES Code
O=C1C([C@]2(C)C(NCCC2)=O)=CC=C(C3=CC4=C(C)C=CC=C4N=C3)N1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Biological target:
PF-06748962 is a potent and selective lactam-based prostaglandin EP3 receptor antagonist.
In vitro activity:
TBD
In vivo activity:
TBD

Preparing Stock Solutions

The following data is based on the product molecular weight 347.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
TBD
In vitro protocol:
TBD
In vivo protocol:
TBD
Futatsugi, K. (2017, April). Discovery of PF-06748962: A potent and selective lactam-based EP3 antagonist. In ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY (Vol. 253). 1155 16TH ST, NW, WASHINGTON, DC 20036 USA: AMER CHEMICAL SOC.