PF-6274484 is an irreversible EGFR kinase inhibitor that covalently reacts with active-site cysteine residues in the ATP binding pocket. PF-6274484 inhibits autophosphorylation of both wild type and mutant EGFR in tumor cells with IC50 values of 5.8 nM and 6.6 nM, respectively.
MedKoo Cat#: 531329
Name: PF-6274484
CAS#: 1035638-91-5
Chemical Formula: C18H14ClFN4O2
Exact Mass: 372.0789
Molecular Weight: 372.78
Elemental Analysis: C, 58.00; H, 3.79; Cl, 9.51; F, 5.10; N, 15.03; O, 8.58
The following data is based on the product molecular weight 372.78 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
