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MedKoo Cat#: 531326 | Name: PFE-360
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

PFE-360, also known asd PF-06685360, is a potent and selective inhibitor of LRRK2 kinase. PFE-360 reversed the aberrant firing pattern of subthalamic neurons induced by AAV-alpha-synuclein overexpression.

Chemical Structure

PFE-360
PFE-360
CAS#1527475-61-1

Theoretical Analysis

MedKoo Cat#: 531326

Name: PFE-360

CAS#: 1527475-61-1

Chemical Formula: C16H16N6O

Exact Mass: 308.1386

Molecular Weight: 308.35

Elemental Analysis: C, 62.32; H, 5.23; N, 27.26; O, 5.19

Price and Availability

Size Price Availability Quantity
5mg USD 550.00 2 Weeks
10mg USD 950.00 2 Weeks
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Related CAS #
No Data
Synonym
PFE-360; PFE 360; PFE360; PF-06685360; PF06685360; PF 06685360; PF-6685360; PF6685360; PF 6685360;
IUPAC/Chemical Name
1-Methyl-4-[4-(4-morpholinyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]-1H-pyrrole-2-carbonitrile
InChi Key
IYQTYHISVSPMSU-UHFFFAOYSA-N
InChi Code
InChI=1S/C16H16N6O/c1-21-9-11(6-12(21)7-17)13-8-18-15-14(13)16(20-10-19-15)22-2-4-23-5-3-22/h6,8-10H,2-5H2,1H3,(H,18,19,20)
SMILES Code
N#CC1=CC(C2=CNC3=NC=NC(N4CCOCC4)=C32)=CN1C
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 308.35 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Weiss A, Sommer P, Wilbertz JH. Phenotypic Profiling of Human Stem Cell- Derived Midbrain Dopaminergic Neurons. J Vis Exp. 2023 Jul 7;(197). doi: 10.3791/65570. PMID: 37486112. 2: Kelly K, Chang A, Hastings L, Abdelmotilib H, West AB. Genetic background influences LRRK2-mediated Rab phosphorylation in the rat brain. Brain Res. 2021 May 15;1759:147372. doi: 10.1016/j.brainres.2021.147372. Epub 2021 Feb 15. PMID: 33600829; PMCID: PMC8006086. 3: Wang S, Kelly K, Brotchie JM, Koprich JB, West AB. Exosome markers of LRRK2 kinase inhibition. NPJ Parkinsons Dis. 2020 Nov 13;6(1):32. doi: 10.1038/s41531-020-00138-7. PMID: 33298972; PMCID: PMC7666125. 4: Ha J, Kang JS, Lee M, Baek A, Kim S, Chung SK, Lee MO, Kim J. Simplified Brain Organoids for Rapid and Robust Modeling of Brain Disease. Front Cell Dev Biol. 2020 Oct 28;8:594090. doi: 10.3389/fcell.2020.594090. PMID: 33195269; PMCID: PMC7655657. 5: Baptista MAS, Merchant K, Barrett T, Bhargava S, Bryce DK, Ellis JM, Estrada AA, Fell MJ, Fiske BK, Fuji RN, Galatsis P, Henry AG, Hill S, Hirst W, Houle C, Kennedy ME, Liu X, Maddess ML, Markgraf C, Mei H, Meier WA, Needle E, Ploch S, Royer C, Rudolph K, Sharma AK, Stepan A, Steyn S, Trost C, Yin Z, Yu H, Wang X, Sherer TB. LRRK2 inhibitors induce reversible changes in nonhuman primate lungs without measurable pulmonary deficits. Sci Transl Med. 2020 Apr 22;12(540):eaav0820. doi: 10.1126/scitranslmed.aav0820. PMID: 32321864. 6: Andersen MA, Sotty F, Jensen PH, Badolo L, Jeggo R, Smith GP, Christensen KV. Long-Term Exposure to PFE-360 in the AAV-α-Synuclein Rat Model: Findings and Implications. eNeuro. 2019 Dec 19;6(6):ENEURO.0453-18.2019. doi: 10.1523/ENEURO.0453-18.2019. PMID: 31685675; PMCID: PMC6978918. 7: Andersen MA, Christensen KV, Badolo L, Smith GP, Jeggo R, Jensen PH, Andersen KJ, Sotty F. Parkinson's disease-like burst firing activity in subthalamic nucleus induced by AAV-α-synuclein is normalized by LRRK2 modulation. Neurobiol Dis. 2018 Aug;116:13-27. doi: 10.1016/j.nbd.2018.04.011. Epub 2018 Apr 20. PMID: 29680709. 8: Andersen MA, Wegener KM, Larsen S, Badolo L, Smith GP, Jeggo R, Jensen PH, Sotty F, Christensen KV, Thougaard A. PFE-360-induced LRRK2 inhibition induces reversible, non-adverse renal changes in rats. Toxicology. 2018 Feb 15;395:15-22. doi: 10.1016/j.tox.2018.01.003. Epub 2018 Jan 4. PMID: 29307545.