MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 584790 | Name: Mivazerol

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Mivazerol is an alpha 2-adrenoceptor agonist.

Chemical Structure

Mivazerol
Mivazerol
CAS#125472-02-8

Theoretical Analysis

MedKoo Cat#: 584790

Name: Mivazerol

CAS#: 125472-02-8

Chemical Formula: C11H11N3O2

Exact Mass: 217.0851

Molecular Weight: 217.23

Elemental Analysis: C, 60.82; H, 5.10; N, 19.34; O, 14.73

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
Mivazerol
IUPAC/Chemical Name
alpha-Imidazol-4-yl-2,3-cresotamide
InChi Key
LRLBFNFGBWYHEF-UHFFFAOYSA-N
InChi Code
InChI=1S/C11H11N3O2/c1-6-2-7(9-4-13-5-14-9)3-8(10(6)15)11(12)16/h2-5,15H,1H3,(H2,12,16)(H,13,14)
SMILES Code
CC1=C(O)C(C(N)=O)=CC(C2=CNC=N2)=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 217.23 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Oliver MF, Goldman L, Julian DG, Holme I. Effect of mivazerol on perioperative cardiac complications during non-cardiac surgery in patients with coronary heart disease: the European Mivazerol Trial (EMIT). Anesthesiology. 1999 Oct;91(4):951-61. PubMed PMID: 10519497. 2: Kimura T, Sato K, Nishikawa T, Tobe Y, Masaki Y. Effect of mivazerol, a alpha-agonist, on striatal norepinephrine concentration during transient forebrain ischemia in rats. Acta Anaesthesiol Scand. 2008 Aug;52(7):997-1002. doi: 10.1111/j.1399-6576.2008.01683.x. Epub 2008 May 20. PubMed PMID: 18494845. 3: Zhang X, Kindel GH, Wülfert E, Hanin I. Effects of immobilization stress on hippocampal monoamine release: modification by mivazerol, a new alpha 2-adrenoceptor agonist. Neuropharmacology. 1995 Dec;34(12):1661-72. PubMed PMID: 8788964. 4: Roekaerts PM, Prinzen FW, Willigers HM, De Lange S. The effects of alpha 2-adrenergic stimulation with mivazerol on myocardial blood flow and function during coronary artery stenosis in anesthetized dogs. Anesth Analg. 1996 Apr;82(4):702-11. PubMed PMID: 8615484. 5: Richer C, Gobert J, Noyer M, Wülfert E, Giudicelli JF. Peripheral alpha 2-adrenoceptor-mediated sympathoinhibitory effects of mivazerol. Fundam Clin Pharmacol. 1996;10(6):529-37. PubMed PMID: 8985723. 6: Guyaux M, Gobert J, Noyer M, Vandevelde M, Wülfert E. Mivazerol prevents the tachycardia caused by emergence from halothane anesthesia partly through activation of spinal alpha 2-adrenoceptors. Acta Anaesthesiol Scand. 1998 Feb;42(2):238-45. PubMed PMID: 9509210. 7: Zhang X, Kindel G, Wülfert E, Hanin I. Mivazerol inhibits intrathecal release of glutamate evoked by halothane withdrawal in rats. Acta Anaesthesiol Scand. 1998 Sep;42(8):1004-9. PubMed PMID: 9773147. 8: Apitzsch H, Olthoff D, Thieme V, Vetter B, Wiegel M. [The effects of perioperative continuous administration of mivazerol on early postoperative hemodynamics and plasma catecholamines after major surgery]. Anasthesiol Intensivmed Notfallmed Schmerzther. 2000 Aug;35(8):515-22. German. PubMed PMID: 10992963. 9: Zhang X, Wülfert E, Hanin I. Mivazerol, a new alpha 2-adrenergic agonist, blunts cardiovascular effects following surgical stress in pentobarbital-anesthetized rats. Acta Anaesthesiol Scand. 1997 Jun;41(6):694-700. PubMed PMID: 9241327. 10: Kim SY, Raikoff K, Wülfert E, Hanin I. Mivazerol, a selective alpha 2-adrenoceptor agonist, attenuates tachycardia by intrathecal injection of N-methyl-D-aspartate in the rat. Eur J Pharmacol. 1996 Dec 5;316(2-3):249-52. PubMed PMID: 8982694. 11: Bruandet N, Rentero N, Debeer L, Quintin L. Catecholamine activation in the vasomotor center on emergence from anesthesia: the effects of alpha2 agonists. Anesth Analg. 1998 Feb;86(2):240-5. PubMed PMID: 9459226. 12: Flamez A, Gillard M, De Backer JP, Vauquelin G, Noyer M. The novel alpha 2-adrenoceptor agonist [3H]mivazerol binds to non-adrenergic binding sites in human striatum membranes that are distinct from imidazoline receptors. Neurochem Int. 1997 Jul;31(1):125-9. PubMed PMID: 9185172. 13: El Tamer A, Prokopenko I, Wülfert E, Hanin I. Mivazerol, a novel alpha2-agonist and potential anti-ischemic drug, inhibits KC1-stimulated neurotransmitter release in rat nervous tissue preparations. J Neurochem. 1996 Aug;67(2):636-44. PubMed PMID: 8764590. 14: Perioperative sympatholysis. Beneficial effects of the alpha 2-adrenoceptor agonist mivazerol on hemodynamic stability and myocardial ischemia. McSPI--Europe Research Group. Anesthesiology. 1997 Feb;86(2):346-63. PubMed PMID: 9054253. 15: Bickler PE, Hansen BM. Alpha 2-adrenergic agonists reduce glutamate release and glutamate receptor-mediated calcium changes in hippocampal slices during hypoxia. Neuropharmacology. 1996 Jun;35(6):679-87. PubMed PMID: 8887976. 16: Kim SY, Raikoff K, Wülfert E, Hanin I. Bradycardia induced by mivazerol, a selective alpha 2-adrenoceptor agonist, is amplified during mild hypothermia in the pentobarbital-anesthetized rat. Cardiovasc Drugs Ther. 1997 Dec;11(6):751-5. PubMed PMID: 9512870. 17: Riemersma RA, Debeer LJ. Effect of mivazerol on myocardial lactate production, blood flow and electrocardiographic signs of ischaemia induced by coronary artery ligation in the anaesthetised dog. Arzneimittelforschung. 1997 Jan;47(1):10-3. PubMed PMID: 9037436. 18: Wright RA, Decroly P, Kharkevitch T, Oliver MF. Exercise tolerance in angina is improved by mivazerol--an alpha 2-adrenoceptor agonist. Cardiovasc Drugs Ther. 1993 Dec;7(6):929-34. PubMed PMID: 7912103. 19: Duncan D, Sankar A, Beattie WS, Wijeysundera DN. Alpha-2 adrenergic agonists for the prevention of cardiac complications among adults undergoing surgery. Cochrane Database Syst Rev. 2018 Mar 6;3:CD004126. doi: 10.1002/14651858.CD004126.pub3. Review. PubMed PMID: 29509957. 20: Wijeysundera DN, Bender JS, Beattie WS. Alpha-2 adrenergic agonists for the prevention of cardiac complications among patients undergoing surgery. Cochrane Database Syst Rev. 2009 Oct 7;(4):CD004126. doi: 10.1002/14651858.CD004126.pub2. Review. Update in: Cochrane Database Syst Rev. 2018 Mar 06;3:CD004126. PubMed PMID: 19821319.