CRS400393 | Antimycobacterial Agent

MedKoo Cat#: 564837 | Name: CRS400393

Description:

WARNING: This product is for research use only, not for human or veterinary use.

CRS400393 is a potent and mycobacteria-specific antimycobacterial agent which targets MmpL3, which is a mycobacterial mycolic acid transporter.

Chemical Structure

CRS400393

CAS#NONE

Theoretical Analysis

MedKoo Cat#: 564837

Name: CRS400393

CAS#: NONE

Chemical Formula: C19H21F3N2O2S

Exact Mass: 398.1276

Molecular Weight: 398.44

Elemental Analysis: C, 57.28; H, 5.31; F, 14.30; N, 7.03; O, 8.03; S, 8.05

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

CRS-400393; CRS 400393; CRS400393

IUPAC/Chemical Name

5-Methyl-N-(6-(trifluoromethoxy)benzo[d]thiazol-2-yl)bicyclo[3.3.1]nonane-1-carboxamide

InChi Key

DJVRLBSDVPLXGU-UHFFFAOYSA-N

InChi Code

InChI=1S/C19H21F3N2O2S/c1-17-6-2-8-18(11-17,9-3-7-17)15(25)24-16-23-13-5-4-12(10-14(13)27-16)26-19(20,21)22/h4-5,10H,2-3,6-9,11H2,1H3,(H,23,24,25)

SMILES Code

O=C(C1(C2)CCCC2(C)CCC1)NC3=NC4=CC=C(OC(F)(F)F)C=C4S3

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 398.44 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Graham J, Wong CE, Day J, McFaddin E, Ochsner U, Hoang T, Young CL, Ribble W, DeGroote MA, Jarvis T, Sun X. Discovery of benzothiazole amides as potent antimycobacterial agents. Bioorg Med Chem Lett. 2018 Oct 15;28(19):3177-3181. doi: 10.1016/j.bmcl.2018.08.026. Epub 2018 Aug 25. PubMed PMID: 30172617; PubMed Central PMCID: PMC6263154.