Ilepatril | CAS# 473289-62-2 | Vasopeptidase Inhibitor

MedKoo Cat#: 573339 | Name: Ilepatril

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Ilepatril, also known as AVE-7688, is a vasopeptidase inhibitor for the treatment of hypertension.

Chemical Structure

Ilepatril

CAS#473289-62-2

Theoretical Analysis

MedKoo Cat#: 573339

Name: Ilepatril

CAS#: 473289-62-2

Chemical Formula: C22H28N2O5S

Exact Mass: 432.1719

Molecular Weight: 432.54

Elemental Analysis: C, 61.09; H, 6.53; N, 6.48; O, 18.49; S, 7.41

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

AVE-7688, Ilepatril

IUPAC/Chemical Name

(4S,7S,12bR)-7-((S)-2-(acetylthio)-3-methylbutanamido)-6-oxo-1,2,3,4,6,7,8,12b-octahydrobenzo[c]pyrido[1,2-a]azepine-4-carboxylic acid

InChi Key

FXKFFTMLFPWYFH-RDGPPVDQSA-N

InChi Code

1S/C22H28N2O5S/c1-12(2)19(30-13(3)25)20(26)23-16-11-14-7-4-5-8-15(14)17-9-6-10-18(22(28)29)24(17)21(16)27/h4-5,7-8,12,16-19H,6,9-11H2,1-3H3,(H,23,26)(H,28,29)/t16-,17+,18-,19-/m0/s1

SMILES Code

[H][C@@]1(C2=CC=CC=C2C[C@@H]3NC([C@@H](SC(C)=O)C(C)C)=O)N([C@H](C(O)=O)CCC1)C3=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 432.54 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Davidson EP, Coppey LJ, Yorek MA. Early loss of innervation of cornea epithelium in streptozotocin-induced type 1 diabetic rats: improvement with ilepatril treatment. Invest Ophthalmol Vis Sci. 2012 Dec 7;53(13):8067-74. doi: 10.1167/iovs.12-10826. PubMed PMID: 23169880; PubMed Central PMCID: PMC3517272. 2: Davidson EP, Coppey LJ, Holmes A, Dake B, Yorek MA. Effect of treatment of high fat fed/low dose streptozotocin-diabetic rats with Ilepatril on vascular and neural complications. Eur J Pharmacol. 2011 Oct 15;668(3):497-506. doi: 10.1016/j.ejphar.2011.07.016. Epub 2011 Jul 28. PubMed PMID: 21816138; PubMed Central PMCID: PMC3185159. 3: Coppey L, Davidson E, Lu B, Gerard C, Yorek M. Vasopeptidase inhibitor ilepatril (AVE7688) prevents obesity- and diabetes-induced neuropathy in C57Bl/6J mice. Neuropharmacology. 2011 Feb-Mar;60(2-3):259-66. doi: 10.1016/j.neuropharm.2010.09.008. Epub 2010 Sep 16. PubMed PMID: 20849865; PubMed Central PMCID: PMC3014404. 4: Tabrizchi R. Ilepatril (AVE-7688), a vasopeptidase inhibitor for the treatment of hypertension. Curr Opin Investig Drugs. 2008 Mar;9(3):301-9. Review. PubMed PMID: 18311667.