MedKoo Cat#: 564810 | Name: MLS6585
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

MLS6585 is a positive allosteric modulator of the D1 dopamine receptor which acts at diverse binding sites.

Chemical Structure

MLS6585
CAS#389080-71-1

Theoretical Analysis

MedKoo Cat#: 564810

Name: MLS6585

CAS#: 389080-71-1

Chemical Formula: C19H23N3O2S

Exact Mass: 357.1511

Molecular Weight: 357.47

Elemental Analysis: C, 63.84; H, 6.49; N, 11.76; O, 8.95; S, 8.97

Price and Availability

Size Price Availability Quantity
5mg USD 450.00 2 weeks
25mg USD 1,250.00 2 Weeks
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Related CAS #
No Data
Synonym
MLS-6585; MLS 6585; MLS6585
IUPAC/Chemical Name
N-(6-(tert-Butyl)-3-carbamoyl-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)isonicotinamide
InChi Key
IMEICQDRTCGLFX-UHFFFAOYSA-N
InChi Code
InChI=1S/C19H23N3O2S/c1-19(2,3)12-4-5-13-14(10-12)25-18(15(13)16(20)23)22-17(24)11-6-8-21-9-7-11/h6-9,12H,4-5,10H2,1-3H3,(H2,20,23)(H,22,24)
SMILES Code
O=C(NC1=C(C(N)=O)C(CCC(C(C)(C)C)C2)=C2S1)C3=CC=NC=C3
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Certificate of Analysis
Safety Data Sheet (SDS)
Biological target:
MLS6585 is a positive allosteric modulator of the D1 dopamine receptor which acts at diverse binding sites.
In vitro activity:
TBD
In vivo activity:
TBD

Preparing Stock Solutions

The following data is based on the product molecular weight 357.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
TBD
In vitro protocol:
TBD
In vivo protocol:
TBD
1: Luderman KD, Conroy JL, Free RB, Southall N, Ferrer M, Sanchez-Soto M, Moritz AE, Willette BKA, Fyfe TJ, Jain P, Titus S, Hazelwood LA, Aubé J, Lane JR, Frankowski KJ, Sibley DR. Identification of Positive Allosteric Modulators of the D(1) Dopamine Receptor That Act at Diverse Binding Sites. Mol Pharmacol. 2018 Oct;94(4):1197-1209. doi: 10.1124/mol.118.113175. Epub 2018 Aug 1. PubMed PMID: 30068735; PubMed Central PMCID: PMC6117505.