TCSA | CAS# 106480-60-8 | Morphogenesis/Biofilm/Cell Invasion Inhibitor

MedKoo Cat#: 564809 | Name: TCSA

Description:

WARNING: This product is for research use only, not for human or veterinary use.

TCSA is an inhibitor of fungal morphogenesis, biofilm formation, and host cell invasion.

Chemical Structure

TCSA

CAS#106480-60-8

Theoretical Analysis

MedKoo Cat#: 564809

Name: TCSA

CAS#: 106480-60-8

Chemical Formula: C13H8Cl3NO2

Exact Mass: 314.9621

Molecular Weight: 316.56

Elemental Analysis: C, 49.32; H, 2.55; Cl, 33.60; N, 4.42; O, 10.11

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

Tri-Chloro-Salicyanilide; TCSA

IUPAC/Chemical Name

5-Chloro-N-(3,5-dichlorophenyl)-2-hydroxybenzamide

InChi Key

FJIIZNKTKISOBM-UHFFFAOYSA-N

InChi Code

InChI=1S/C13H8Cl3NO2/c14-7-1-2-12(18)11(6-7)13(19)17-10-4-8(15)3-9(16)5-10/h1-6,18H,(H,17,19)

SMILES Code

O=C(NC1=CC(Cl)=CC(Cl)=C1)C2=CC(Cl)=CC=C2O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 316.56 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Lee IY, Gruber TD, Samuels A, Yun M, Nam B, Kang M, Crowley K, Winterroth B, Boshoff HI, Barry CE 3rd. Structure-activity relationships of antitubercular salicylanilides consistent with disruption of the proton gradient via proton shuttling. Bioorg Med Chem. 2013 Jan 1;21(1):114-26. doi: 10.1016/j.bmc.2012.10.056. Epub 2012 Nov 15. PubMed PMID: 23211970; PubMed Central PMCID: PMC3525752. 2: Fomovska A, Wood RD, Mui E, Dubey JP, Ferreira LR, Hickman MR, Lee PJ, Leed SE, Auschwitz JM, Welsh WJ, Sommerville C, Woods S, Roberts C, McLeod R. Salicylanilide inhibitors of Toxoplasma gondii. J Med Chem. 2012 Oct 11;55(19):8375-91. doi: 10.1021/jm3007596. Epub 2012 Sep 26. PubMed PMID: 22970937; PubMed Central PMCID: PMC3498903.