MedKoo Cat#: 573311 | Name: Tolperisone free base

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Tolperisone free base is a centrally acting muscle relaxant that has been used for the symptomatic treatment of spasticity and muscle spasm.

Chemical Structure

Tolperisone free base
CAS#728-88-1

Theoretical Analysis

MedKoo Cat#: 573311

Name: Tolperisone free base

CAS#: 728-88-1

Chemical Formula: C16H23NO

Exact Mass: 245.1780

Molecular Weight: 245.37

Elemental Analysis: C, 78.32; H, 9.45; N, 5.71; O, 6.52

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Synonym
Atmosgen free base, Besnoline free base, Menopatol, Mideton, Mydeton, Mydocalm, Roystajin free base, Tolperisone free base, Tolperisone,
IUPAC/Chemical Name
1-Propanone, 2-methyl-1-(4-methylphenyl)-3-(1-piperidinyl)- (9CI)
InChi Key
FSKFPVLPFLJRQB-UHFFFAOYSA-N
InChi Code
1S/C16H23NO/c1-13-6-8-15(9-7-13)16(18)14(2)12-17-10-4-3-5-11-17/h6-9,14H,3-5,10-12H2,1-2H3
SMILES Code
c1(C([C@@H](CN2CCCCC2)C)=O)ccc(C)cc1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 245.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Luo D, Wu G, Ji Y, Zhang Z, He F, Mou X, Zhu Q, Yang B. The comparative study of clinical efficacy and safety of baclofen vs tolperisone in spasticity caused by spinal cord injury. Saudi Pharm J. 2017 May;25(4):655-659. doi: 10.1016/j.jsps.2017.04.041. Epub 2017 May 7. PubMed PMID: 28579907; PubMed Central PMCID: PMC5447437. 2: Agarwal S, Patel T, Shah N, Patel BM. Comparative study of therapeutic response to baclofen vs tolperisone in spasticity. Biomed Pharmacother. 2017 Mar;87:628-635. doi: 10.1016/j.biopha.2017.01.005. Epub 2017 Jan 10. Erratum in: Biomed Pharmacother. 2017 Aug;92:1140. PubMed PMID: 28086137. 3: Tekes K. Basic aspects of the pharmacodynamics of tolperisone, a widely applicable centrally acting muscle relaxant. Open Med Chem J. 2014 Jul 11;8:17-22. doi: 10.2174/1874104501408010017. eCollection 2014. PubMed PMID: 25132868; PubMed Central PMCID: PMC4133921.