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MedKoo Cat#: 564797 | Name: Benfluron Hydrochloride

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Benfluron Hydrochloride is an inhibitor of HIV-1 Rev function which also acts as a cytostatic agent with substantial antiretroviral activity.

Chemical Structure

Benfluron Hydrochloride
Benfluron Hydrochloride
CAS#80427-58-3

Theoretical Analysis

MedKoo Cat#: 564797

Name: Benfluron Hydrochloride

CAS#: 80427-58-3

Chemical Formula: C21H20ClNO2

Exact Mass: 353.1183

Molecular Weight: 353.85

Elemental Analysis: C, 71.28; H, 5.70; Cl, 10.02; N, 3.96; O, 9.04

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
VUFB-13468 hydrochloride; VUFB-13468 hydrochloride; VUFB-13468 HCl; Benfluron Hydrochloride; Benfluron HCl
IUPAC/Chemical Name
5-[2-(Dimethylamino)ethoxy]benzo[c]fluoren-7-one hydrochloride
InChi Key
FEDBYSNFQHOGCJ-UHFFFAOYSA-N
InChi Code
InChI=1S/C21H19NO2.ClH/c1-22(2)11-12-24-19-13-18-20(15-8-4-3-7-14(15)19)16-9-5-6-10-17(16)21(18)23;/h3-10,13H,11-12H2,1-2H3;1H
SMILES Code
O=C1C2=C(C3=C1C=CC=C3)C4=CC=CC=C4C(OCCN(C)C)=C2.[H]Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 353.85 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Kucera R, Nobilis M, Skálová L, Szotáková B, Císar P, Jira T, Klimes J, Wsól V. Use of chiral liquid chromatography for the evaluation of stereospecificity in the carbonyl reduction of potential benzo[c]fluorene antineoplastics benfluron and dimefluron in various species. J Pharm Biomed Anal. 2005 Apr 29;37(5):1049-57. Epub 2004 Nov 28. PubMed PMID: 15862685. 2: Netopilová M, Veselá J, Drsata J. Influence of 5-[2-(N,N-dimethylamino)ethoxy]-7-oxo-7H-benzo(C)fluorene hydrochloride (benflurone) on the activity of rat liver aspartate and alanine aminotransferases. Drug Metabol Drug Interact. 1991;9(3-4):301-9. PubMed PMID: 1824083. 3: Veselá J, Drsata J. [The effect of 5-[2-(N,N-dimethylamino)ethoxy]-7-oxo-7H-benzo(c) fluorene hydrochloride (Benfluron, a cytostatic) on ornithine decarboxylase activity in the regenerating rat liver in vivo]. Cesk Farm. 1988 Jul;37(6):251-4. Czech. PubMed PMID: 3180267. 4: Francová V, Smolík S, Schlehrová M, Ráz K, Selecká A, Franc Z, Frühaufová-Ausková M, Rezábek K, Vancurová I, Krepelka J. Derivatives of benzo(c)fluorene. XVI. Absorption, distribution and elimination of 3H-benflurone, 5-(2-N,N-dimethylamino)ethoxy)-7-oxo-7H-benzo(c)fluorene hydrochloride in rats after oral and intravenous administration. Neoplasma. 1985;32(5):529-36. PubMed PMID: 4069287. 5: Hrubá A, Paluska E, Pujman V, Polednová V, Chudomel V, Krepelka J. Derivatives of benzo(c)fluorene. XI. Effect of Benfluron on hemopoietic stem cells. Neoplasma. 1984;31(4):407-13. PubMed PMID: 6472513.