N-n-Butyl Haloperidol Iodide | Autophagy Inhibitor

MedKoo Cat#: 564794 | Name: N-n-Butyl Haloperidol Iodide

Description:

WARNING: This product is for research use only, not for human or veterinary use.

N-n-Butyl haloperidol iodide is an inhibitor of autophagy which protects cardiomyocytes against hypoxia and reoxygenation injury.

Chemical Structure

N-n-Butyl Haloperidol Iodide

CAS#NONE

Theoretical Analysis

MedKoo Cat#: 564794

Name: N-n-Butyl Haloperidol Iodide

CAS#: NONE

Chemical Formula: C25H32ClFINO2

Exact Mass: 0.0000

Molecular Weight: 559.89

Elemental Analysis: C, 53.63; H, 5.76; Cl, 6.33; F, 3.39; I, 22.67; N, 2.50; O, 5.72

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

N-n-Butyl haloperidol iodide; N-n-Butylhaloperidol iodide

IUPAC/Chemical Name

1-Butyl-4-(4-chloro-phenyl)-1-[4-(4-fluoro-phenyl)-4-oxo-butyl]-4-hydroxy-piperidinium iodide

InChi Key

JZOLZUFLPKVJDH-UHFFFAOYSA-M

InChi Code

InChI=1S/C25H32ClFNO2.HI/c1-2-3-16-28(17-4-5-24(29)20-6-12-23(27)13-7-20)18-14-25(30,15-19-28)21-8-10-22(26)11-9-21;/h6-13,30H,2-5,14-19H2,1H3;1H/q+1;/p-1

SMILES Code

OC1(C2=CC=C(Cl)C=C2)CC[N+](CCCC(C3=CC=C(F)C=C3)=O)(CCCC)CC1.[I-]

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 559.89 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Lu B, Wang B, Zhong S, Zhang Y, Gao F, Chen Y, Zheng F, Shi G. N-n-butyl haloperidol iodide ameliorates hypoxia/reoxygenation injury through modulating the LKB1/AMPK/ROS pathway in cardiac microvascular endothelial cells. Oncotarget. 2016 Jun 7;7(23):34800-10. doi: 10.18632/oncotarget.9186. PubMed PMID: 27166184; PubMed Central PMCID: PMC5085190. 2: Wang B, Zhong S, Zheng F, Zhang Y, Gao F, Chen Y, Lu B, Xu H, Shi G. N-n-butyl haloperidol iodide protects cardiomyocytes against hypoxia/reoxygenation injury by inhibiting autophagy. Oncotarget. 2015 Sep 22;6(28):24709-21. doi: 10.18632/oncotarget.5077. PubMed PMID: 26359352; PubMed Central PMCID: PMC4694790. 3: Zhang Y, Liao H, Zhong S, Gao F, Chen Y, Huang Z, Lu S, Sun T, Wang B, Li W, Xu H, Zheng F, Shi G. Effect of N-n-butyl haloperidol iodide on ROS/JNK/Egr-1 signaling in H9c2 cells after hypoxia/reoxygenation. Sci Rep. 2015 Jul 2;5:11809. doi: 10.1038/srep11809. PubMed PMID: 26134032; PubMed Central PMCID: PMC4488875. 4: Huang YP, Gao FF, Wang B, Zheng FC, Zhang YM, Chen YC, Huang ZQ, Zheng YS, Zhong SP, Shi GG. N-n-butyl haloperidol iodide inhibits H2O2-induced Na+/Ca2+-exchanger activation via the Na+/H+ exchanger in rat ventricular myocytes. Drug Des Devel Ther. 2014 Sep 9;8:1257-67. doi: 10.2147/DDDT.S63163. eCollection 2014. PubMed PMID: 25246767; PubMed Central PMCID: PMC4166912. 5: Zhang Y, Chen G, Zhong S, Zheng F, Gao F, Chen Y, Huang Z, Cai W, Li W, Liu X, Zheng Y, Xu H, Shi G. N-n-butyl haloperidol iodide ameliorates cardiomyocytes hypoxia/reoxygenation injury by extracellular calcium-dependent and -independent mechanisms. Oxid Med Cell Longev. 2013;2013:912310. doi: 10.1155/2013/912310. Epub 2013 Nov 12. PubMed PMID: 24392181; PubMed Central PMCID: PMC3857550.