Mofebutazone | CAS#2210-63-1 | antiinflammatory

MedKoo Cat#: 584767 | Name: Mofebutazone

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Mofebutazone inhibits the immunological release of prostaglandins as well as leukotrienes.

Chemical Structure

Mofebutazone

CAS#2210-63-1

Theoretical Analysis

MedKoo Cat#: 584767

Name: Mofebutazone

CAS#: 2210-63-1

Chemical Formula: C13H16N2O2

Exact Mass: 232.1212

Molecular Weight: 232.28

Elemental Analysis: C, 67.22; H, 6.94; N, 12.06; O, 13.78

Price and Availability

Size	Price	Availability	Quantity
250mg	USD 315.00

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Related CAS #

No Data

Synonym

Mofebutazone; Butazone; Corbuton

IUPAC/Chemical Name

3,5-Pyrazolidinedione, 4-butyl-1-phenyl-

InChi Key

REOJLIXKJWXUGB-UHFFFAOYSA-N

InChi Code

InChI=1S/C13H16N2O2/c1-2-3-9-11-12(16)14-15(13(11)17)10-7-5-4-6-8-10/h4-8,11H,2-3,9H2,1H3,(H,14,16)

SMILES Code

O=C(C1CCCC)NN(C2=CC=CC=C2)C1=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Product Data

Product Data

Instruction

View handling instruction

Biological target:

Mofebutazone inhibits the immunological release of prostaglandins as well as leukotrienes.

In vitro activity:

TBD

In vivo activity:

TBD

Preparing Stock Solutions

The following data is based on the product molecular weight 232.28 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

TBD

In vitro protocol:

TBD

In vivo protocol:

TBD

1: Paradies HH. Structure of phenylbutazone and mofebutazone in the crystalline state and in solution. J Pharm Sci. 1987 Dec;76(12):920-9. PubMed PMID: 3440938. 2: Matthei U, Grabensee B, Loew D. The interaction of mofebutazone with furosemide. Curr Med Res Opin. 1987;10(9):638-44. PubMed PMID: 3481307. 3: Khayyal MT, El-Ghazaly M, El-Khatib AS, Hatem A. Tolerability of mofebutazone in asthmatic patients. Int J Clin Pharmacol Res. 1995;15(4):145-51. PubMed PMID: 8871264. 4: Kassem MA, Schulte KE. Pharmacokinetics of [4-14C] mofebutazone after oral administration in man. Eur J Drug Metab Pharmacokinet. 1984 Jul-Sep;9(3):223-7. PubMed PMID: 6519123. 5: Kamp J, Loew D, Barkow D, Deister J, Schuster O, Knoell HE. [Kinetics of mofebutazone in plasma and synovial fluid]. Z Rheumatol. 1984 Jul-Aug;43(4):179-81. German. PubMed PMID: 6495891. 6: Neumüller J, Tohidast-Akrad M. Comparative in vitro investigations of the influence of mofebutazone, phenylbutazone and diclofenac on phagocytosis and respiratory burst of human peripheral blood leucocytes. Arzneimittelforschung. 1994 May;44(5):636-41. PubMed PMID: 8024638. 7: Loew D, Schuster O, Knoell HE, Graul EH. [Pharmacology, toxicology and pharmacokinetics of mofebutazone]. Z Rheumatol. 1985 Jul-Aug;44(4):186-92. German. PubMed PMID: 4050150. 8: Bass VM, Mrongovius RI, Schulte KE. Disposition of [4-14C]mofebutazone in the rat. Eur J Drug Metab Pharmacokinet. 1980;5(4):201-6. PubMed PMID: 7250143. 9: Loew D, Schuster O, Graul EH. [Distribution of 4-14C-mofebutazone in the rat]. Z Rheumatol. 1986 Mar-Apr;45(2):83-6. German. PubMed PMID: 3727816. 10: ZICHA L, BERGNER D, MILLER P, KRATSCH H. [COMPARATIVE STUDIES ON HISTAMINE AND SEROTONIN ANTAGONISM OF MONOPHENYLBUTAZONE, DIMETHYLAMINOETHANOL BITARTRATE, ISOPROPYLANTIPYRINE, CARISOPRODOL, TRASYLOL, RESPLANT AND PITRESSIN IN THE GUINEA PIG ASTHMA TEST. 1]. Allerg Asthma (Leipz). 1964 Aug;10:223-32. German. PubMed PMID: 14313419. 11: Woodbury JF, Turner WA, Tiongson R. Rheumatoid arthritis: comparison of treatment with monophenylbutazone and phenylbutazone. Can Med Assoc J. 1969 Dec 27;101(13):69-71. PubMed PMID: 4903691; PubMed Central PMCID: PMC1946452. 12: van der Pol HJ. [Monophenylbutazone]. Pharm Weekbl. 1965 Dec 3;100(49):1446-7. Dutch. PubMed PMID: 5847216. 13: BERGNER D, ZICHA L, KRATSCH H, MILLER P. [COMPARATIVE STUDIES ON ACETYLCHOLINE ANTAGONISM OF MONOPHENYLBUTAZONE, DIMETHYLAMINOETHANOL BITARTRATE, ISOPROPYLANTIPYRINE, CARISOPRODOL, TRASYLOL, RESPLANT AND PITRESSIN IN THE GUINEA PIG ASTHMA TEST. II]. Allerg Asthma (Leipz). 1964 Aug;10:233-40. German. PubMed PMID: 14293392. 14: Partsch G. Influence of mofebutazone in comparison to phenylbutazone on the adenosine triphosphate level of polymorphonuclear cells and their migration. Arzneimittelforschung. 1992 Nov;42(11):1336-8. PubMed PMID: 1492846. 15: Khayyal MT, el-Khatib AS, el-Ghazaly M, Hatem A. Inhibition of leukotriene release by mofebutazone: a possible clinical advantage. Int J Clin Pharmacol Res. 1993;13(5):255-61. PubMed PMID: 8200720. 16: Lanz R, Peskar BA, Brune K. The effects of acidic and nonacidic pyrazoles on arachidonic acid metabolism in mouse peritoneal macrophages. Agents Actions Suppl. 1986;19:125-35. PubMed PMID: 3092599. 17: Salzmann U. [Thin-layer chromatography of 1-phenyl-4n-butyl-3,5-dioxopyrazolidine (Monophenylbutazone)]. Pharm Acta Helv. 1971 Dec;46(12):721-9. German. PubMed PMID: 5143003. 18: Stoltz M, Oliver DW, Wessels PL, Chalmers AA. High-resolution solid-state carbon-13 nuclear magnetic resonance spectra of mofebutazone, phenylbutazone, and oxyphenbutazone in relation to X-ray crystallographic data. J Pharm Sci. 1991 Apr;80(4):357-62. PubMed PMID: 1865336. 19: Speders S. [Mofebutazone--evaluation of possible interaction with glibenclamide]. Fortschr Med. 1993 Aug 20;111(22-23):366-8. German. PubMed PMID: 8406274. 20: Kassem MA, Schulte KE. Influence of phenylbutazone, mofebutazone and aspirin on the pharmacokinetics of dexamethasone in the rat. Eur J Drug Metab Pharmacokinet. 1981;6(1):11-20. PubMed PMID: 7250148.