MedKoo Cat#: 471017 | Name: VH 032 Linker 3
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

VH 032 Linker 3 is a derivative of the proteolysis-targeting chimera technology (PROTAC) for PROTAC research and development; by incorporating an E3 ligase ligand and a short alkyl linker, it is ready for conjugation to a target protein ligand.

Chemical Structure

VH 032 Linker 3
VH 032 Linker 3
CAS#Unknown

Theoretical Analysis

MedKoo Cat#: 471017

Name: VH 032 Linker 3

CAS#: Unknown

Chemical Formula: C27H40ClN5O4S

Exact Mass:

Molecular Weight: 566.16

Elemental Analysis: 57.28; H, 7.12; Cl, 6.26; N, 12.37; O, 11.30; S, 5.66

Price and Availability

Size Price Availability Quantity
10mg USD 250.00
25mg USD 420.00
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Related CAS #
No Data
Synonym
VH 032 Linker 3, VH032 Linker 3; VH-032 Linker 3
IUPAC/Chemical Name
(2S,4R)-1-((S)-2-(5-aminopentanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride
InChi Key
HJICCZROGLAHNB-BIBCNAKVSA-N
InChi Code
InChI=1S/C27H39N5O4S.ClH/c1-17-23(37-16-30-17)19-10-8-18(9-11-19)14-29-25(35)21-13-20(33)15-32(21)26(36)24(27(2,3)4)31-22(34)7-5-6-12-28;/h8-11,16,20-21,24,33H,5-7,12-15,28H2,1-4H3,(H,29,35)(H,31,34);1H/t20-,21+,24-;/m1./s1
SMILES Code
O=C(N1C[C@@H](C[C@H]1C(NCC2=CC=C(C=C2)C3=C(N=CS3)C)=O)O)[C@H](C(C)(C)C)NC(CCCCN)=O.Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Certificate of Analysis
Safety Data Sheet (SDS)

Preparing Stock Solutions

The following data is based on the product molecular weight 566.16 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Salami et al (2017) Waste disposal-An attractive strategy for cancer therapy. Science 355 1163 PMID: 28302825