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MedKoo Cat#: 531097 | Name: Fipronil sulfone
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Fipronil sulfone is an insecticide fipronil and its metabolite fipronil sulphone inhibit the rat alpha1beta2gamma2L GABA(A) receptor.

Chemical Structure

Fipronil sulfone
Fipronil sulfone
CAS#120068-36-2

Theoretical Analysis

MedKoo Cat#: 531097

Name: Fipronil sulfone

CAS#: 120068-36-2

Chemical Formula: C12H4Cl2F6N4O2S

Exact Mass: 451.9336

Molecular Weight: 453.14

Elemental Analysis: C, 31.81; H, 0.89; Cl, 15.65; F, 25.16; N, 12.36; O, 7.06; S, 7.08

Price and Availability

Size Price Availability Quantity
50mg USD 550.00 2 Weeks
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Related CAS #
No Data
Synonym
Fipronil sulfone; Fipronil-sulfone; Fipronil sulphone; MB-46136; MB 46136; MB46136
IUPAC/Chemical Name
1H-Pyrazole-3-carbonitrile, 5-amino-1-(2,6-dichloro-4-(trifluoromethyl)phenyl)-4-((trifluoromethyl)sulfonyl)-
InChi Key
LGHZJDKSVUTELU-UHFFFAOYSA-N
InChi Code
InChI=1S/C12H4Cl2F6N4O2S/c13-5-1-4(11(15,16)17)2-6(14)8(5)24-10(22)9(7(3-21)23-24)27(25,26)12(18,19)20/h1-2H,22H2
SMILES Code
N#CC1=NN(C2=C(Cl)C=C(C(F)(F)F)C=C2Cl)C(N)=C1S(=O)(C(F)(F)F)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 453.14 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Wang K, Vasylieva N, Wan D, Eads DA, Yang J, Tretten T, Barnych B, Li J, Li QX, Gee SJ, Hammock BD, Xu T. Quantitative Detection of Fipronil and Fipronil-Sulfone in Sera of Black-Tailed Prairie Dogs and Rats after Oral Exposure to Fipronil by Camel Single-Domain Antibody-Based Immunoassays. Anal Chem. 2018 Dec 6. doi: 10.1021/acs.analchem.8b04653. [Epub ahead of print] PubMed PMID: 30521755. 2: Edwards ED, Woolly EF, McLellan RM, Keyzers RA. Non-detection of honeybee hive contamination following Vespula wasp baiting with protein containing fipronil. PLoS One. 2018 Oct 29;13(10):e0206385. doi: 10.1371/journal.pone.0206385. eCollection 2018. PubMed PMID: 30372501; PubMed Central PMCID: PMC6205613. 3: Li H, You J, Wang WX. Multi-compartmental toxicokinetic modeling of fipronil in tilapia: Accumulation, biotransformation and elimination. J Hazard Mater. 2018 Oct 15;360:420-427. doi: 10.1016/j.jhazmat.2018.07.085. Epub 2018 Aug 3. PubMed PMID: 30138902. 4: Kim DJ, Park SG, Kim DH, Kim SH. SERS-Active-Charged Microgels for Size- and Charge-Selective Molecular Analysis of Complex Biological Samples. Small. 2018 Oct;14(40):e1802520. doi: 10.1002/smll.201802520. Epub 2018 Aug 20. Erratum in: Small. 2018 Dec;14(50):e1804655. PubMed PMID: 30129114. 5: Qu H, Ma R, Wang F, Gao J, Wang P, Zhou Z, Liu D. The effect of biochar on the mitigation of the chiral insecticide fipronil and its metabolites burden on loach (Misgurnus.anguillicaudatus). J Hazard Mater. 2018 Oct 15;360:214-222. doi: 10.1016/j.jhazmat.2018.07.078. Epub 2018 Jul 27. PubMed PMID: 30099364. 6: Zortéa T, Dos Reis TR, Serafini S, de Sousa JP, da Silva AS, Baretta D. Ecotoxicological effect of fipronil and its metabolites on Folsomia candida in tropical soils. Environ Toxicol Pharmacol. 2018 Sep;62:203-209. doi: 10.1016/j.etap.2018.07.011. Epub 2018 Jul 26. PubMed PMID: 30077901. 7: Jinguji H, Ohtsu K, Ueda T, Goka K. Effects of short-term, sublethal fipronil and its metabolite on dragonfly feeding activity. PLoS One. 2018 Jul 11;13(7):e0200299. doi: 10.1371/journal.pone.0200299. eCollection 2018. PubMed PMID: 29995904; PubMed Central PMCID: PMC6040742. 8: Guo Q, Zhao S, Zhang J, Qi K, Du Z, Shao B. Determination of fipronil and its metabolites in chicken egg, muscle and cake by a modified QuEChERS method coupled with LC-MS/MS. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2018 Aug;35(8):1543-1552. doi: 10.1080/19440049.2018.1472395. Epub 2018 Jun 19. PubMed PMID: 29775427. 9: He SW, Zhao YG, Zhang Y, Jin MC, Zhu Y. Hydrophilicity nano-titania coating modified magnetic graphene oxide for pass-through cleanup of fipronil and its metabolites in human blood. J Chromatogr A. 2018 Jun 8;1553:16-24. doi: 10.1016/j.chroma.2018.04.019. Epub 2018 Apr 9. PubMed PMID: 29691057. 10: Cam M, Durieu E, Bodin M, Manousopoulou A, Koslowski S, Vasylieva N, Barnych B, Hammock BD, Bohl B, Koch P, Omori C, Yamamoto K, Hata S, Suzuki T, Karg F, Gizzi P, Haber VE, Bencetic Mihaljevic V, Tavcar B, Portelius E, Pannee J, Blennow K, Zetterberg H, Garbis SD, Auvray P, Gerber H, Fraering J, Fraering PC, Meijer L. Induction of Amyloid-β42 Production by Fipronil and Other Pyrazole Insecticides. J Alzheimers Dis. 2018;62(4):1663-1681. doi: 10.3233/JAD-170875. PubMed PMID: 29504531. 11: Guo D, Shi Y, Li Y, Yi X, Deng X, Xiao W, Wang J, Li X, Liu H, Shen W. [Rapid screening of fipronil and its metabolites in egg and egg products by solid phase extraction-liquid chromatography-quadrupole time-of-flight mass spectrometry]. Se Pu. 2017 Dec 8;35(12):1216-1223. doi: 10.3724/SP.J.1123.2017.09026. Chinese. PubMed PMID: 29372770. 12: Li J, Zheng X, Wang H, Qiu H. [Determination of fipronil and its metabolites in bird eggs by ultra-performance liquid chromatography-tandem mass spectrometry with dispersive solid phase extraction]. Se Pu. 2017 Dec 8;35(12):1211-1215. doi: 10.3724/SP.J.1123.2017.08018. Chinese. PubMed PMID: 29372769. 13: Rong L, Wu X, Xu J, Dong F, Liu X, Pan X, Du P, Wei D, Zheng Y. Simultaneous determination of three pesticides and their metabolites in unprocessed foods using ultraperformance liquid chromatography-tandem mass spectrometry. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2018 Feb;35(2):273-281. doi: 10.1080/19440049.2017.1398419. Epub 2017 Dec 1. PubMed PMID: 29090615. 14: Lyu B, Chen DW, Li JG, Zhou S, Zhao YF. [Analysis of fipronil and metabolites residues distrubution in eggs]. Zhonghua Yu Fang Yi Xue Za Zhi. 2017 Oct 6;51(10):949-953. doi: 10.3760/cma.j.issn.0253-9624.2017.10.015. Chinese. PubMed PMID: 29037000. 15: Gajendiran A, Abraham J. Biomineralisation of fipronil and its major metabolite, fipronil sulfone, by Aspergillus glaucus strain AJAG1 with enzymes studies and bioformulation. 3 Biotech. 2017 Jul;7(3):212. doi: 10.1007/s13205-017-0820-8. Epub 2017 Jul 1. PubMed PMID: 28667652; PubMed Central PMCID: PMC5493570. 16: Ensminger MP, Vasquez M, Tsai HJ, Mohammed S, Van Scoy A, Goodell K, Cho G, Goh KS. Continuous low-level aquatic monitoring (CLAM) samplers for pesticide contaminant screening in urban runoff: Analytical approach and a field test case. Chemosphere. 2017 Oct;184:1028-1035. doi: 10.1016/j.chemosphere.2017.06.085. Epub 2017 Jun 21. PubMed PMID: 28658738. 17: Vasylieva N, Barnych B, Wan D, El-Sheikh EA, Nguyen HM, Wulff H, McMahen R, Strynar M, Gee SJ, Hammock BD. Hydroxy-fipronil is a new urinary biomarker of exposure to fipronil. Environ Int. 2017 Jun;103:91-98. doi: 10.1016/j.envint.2017.03.012. Epub 2017 Mar 23. PubMed PMID: 28343720; PubMed Central PMCID: PMC5432128. 18: Gripp HS, Freitas JS, Almeida EA, Bisinoti MC, Moreira AB. Biochemical effects of fipronil and its metabolites on lipid peroxidation and enzymatic antioxidant defense in tadpoles (Eupemphix nattereri: Leiuperidae). Ecotoxicol Environ Saf. 2017 Feb;136:173-179. doi: 10.1016/j.ecoenv.2016.10.027. Epub 2016 Nov 18. PubMed PMID: 27870966. 19: Sadaria AM, Sutton R, Moran KD, Teerlink J, Brown JV, Halden RU. Passage of fiproles and imidacloprid from urban pest control uses through wastewater treatment plants in northern California, USA. Environ Toxicol Chem. 2017 Jun;36(6):1473-1482. doi: 10.1002/etc.3673. Epub 2016 Dec 16. PubMed PMID: 27808432. 20: Wolfand JM, LeFevre GH, Luthy RG. Metabolization and degradation kinetics of the urban-use pesticide fipronil by white rot fungus Trametes versicolor. Environ Sci Process Impacts. 2016 Oct 12;18(10):1256-1265. PubMed PMID: 27722395.

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