MedKoo Cat#: 573299 | Name: Aspalatone

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Aspalatone is an anti-platelet aggregator (antithrombotic) that has been shown to prolong bleeding time in the mouse model. Aspalatone generates antioxidant and neuroprotective effects against kainic acid-induced epilepsy.

Chemical Structure

Aspalatone
Aspalatone
CAS#147249-33-0

Theoretical Analysis

MedKoo Cat#: 573299

Name: Aspalatone

CAS#: 147249-33-0

Chemical Formula: C15H12O6

Exact Mass: 288.0634

Molecular Weight: 288.26

Elemental Analysis: C, 62.50; H, 4.20; O, 33.30

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Synonym
Aspalatone
IUPAC/Chemical Name
2-Methyl-4-oxo-4H-pyran-3-yl 2-(acetyloxy)benzoate
InChi Key
JVBIZYPCGNCWIT-UHFFFAOYSA-N
InChi Code
1S/C15H12O6/c1-9-14(12(17)7-8-19-9)21-15(18)11-5-3-4-6-13(11)20-10(2)16/h3-8H,1-2H3
SMILES Code
CC(=O)Oc1ccccc1C(=O)OC2=C(C)OC=CC2=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 288.26 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Sonowal H, Pal PB, Shukla K, Ramana KV. Aspalatone Prevents VEGF-Induced Lipid Peroxidation, Migration, Tube Formation, and Dysfunction of Human Aortic Endothelial Cells. Oxid Med Cell Longev. 2017;2017:2769347. doi: 10.1155/2017/2769347. Epub 2017 Jan 24. PubMed PMID: 28243353; PubMed Central PMCID: PMC5294669. 2: Kim HC, Choi DY, Jhoo WK, Lee DW, Koo CH, Kim C. Aspalatone, a new antiplatelet agent, attenuates the neurotoxicity induced by kainic acid in the rat. Life Sci. 1997;61(24):PL 373-81. PubMed PMID: 9399638. 3: Kim C, Nam SW, Choi DY, Choi JH, Park ES, Jhoo WK, Kim HC. A new antithrombotic agent, aspalatone, attenuated cardiotoxicity induced by doxorubicin in the mouse; possible involvement of antioxidant mechanism. Life Sci. 1997;60(4-5):PL75-82. PubMed PMID: 9010492. 4: Suh DY, Yang HO, Kim YC, Han BH. Metabolic fate of the new antithrombotic agent aspalatone in rats. In vivo and in vitro study. Arzneimittelforschung. 1995 Oct;45(10):1071-4. PubMed PMID: 8595061. 5: Han BH, Suh DY, Yang HO, Park YH, Kang YH, Kim YC. Synthesis and antiplatelet effects of the new antithrombotic agent aspalatone with low ulcerogenicity. Arzneimittelforschung. 1994 Oct;44(10):1122-6. PubMed PMID: 7818584.