Asp-4058 hydrochloride is an agonist for sphingosine 1-phosphate receptors 1 and 5. ASP-4058 ameliorates experimental autoimmune encephalomyelitis and preferentially activates S1P1 and S1P5 compared with S1P2, 3, 4 in GTPγS binding assays in vitro. ASP4058 prevented relapse of disease in a mouse model of relapsing-remitting EAE. Although these immunomodulatory effects were comparable to those of fingolimod, ASP4058 showed a wider safety margin than fingolimod for bradycardia and bronchoconstriction in rodents.
MedKoo Cat#: 573296
Name: Asp-4058 hydrochloride
CAS#: 952510-14-4
Chemical Formula: C19H13ClF6N4O2
Exact Mass: 478.0631
Molecular Weight: 478.78
Elemental Analysis: C, 47.66; H, 2.74; Cl, 7.40; F, 23.81; N, 11.70; O, 6.68
The following data is based on the product molecular weight 478.78 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
