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MedKoo Cat#: 573295 | Name: ASP-4000 free base

Description:

WARNING: This product is for research use only, not for human or veterinary use.

ASP-4000 free base is a dipeptidyl peptidase 4 (DPP) inhibitor with antihyperglycemic activity.

Chemical Structure

ASP-4000 free base
ASP-4000 free base
CAS#851510-67-3

Theoretical Analysis

MedKoo Cat#: 573295

Name: ASP-4000 free base

CAS#: 851510-67-3

Chemical Formula: C12H17N3O2

Exact Mass: 235.1321

Molecular Weight: 235.29

Elemental Analysis: C, 61.26; H, 7.28; N, 17.86; O, 13.60

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
ASP-4000 free base
IUPAC/Chemical Name
2-Pyrrolidinecarbonitrile, 1-(((1R,3S,4S,6R)-6-hydroxy-2-azabicyclo(2.2.1)hept-3-yl)carbonyl)-, (2S)-
InChi Key
FVTNKOGXEQXHHE-DAWVFNFOSA-N
InChi Code
1S/C12H17N3O2/c13-6-8-2-1-3-15(8)12(17)11-7-4-9(14-11)10(16)5-7/h7-11,14,16H,1-5H2/t7-,8-,9+,10+,11-/m0/s1
SMILES Code
C1C[C@H](N(C1)C(=O)[C@@H]2[C@H]3C[C@@H](N2)[C@@H](C3)O)C#N
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 235.29 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Tanaka-Amino K, Hatakeyama Y, Takakura S, Mutoh S. Constitutive increase in active GLP-1 levels by the DPP4 inhibitor ASP4000 on a new meal tolerance test in Zucker fatty rats. Pharmacol Res. 2009 Oct;60(4):264-9. doi: 10.1016/j.phrs.2009.03.018. Epub 2009 Apr 7. PubMed PMID: 19520592. 2: Tanaka-Amino K, Matsumoto K, Hatakeyama Y, Takakura S, Mutoh S. ASP4000, a slow-binding dipeptidyl peptidase 4 inhibitor, has antihyperglycemic activity of long duration in Zucker fatty rats. Acta Diabetol. 2010 Mar;47(1):43-8. doi: 10.1007/s00592-009-0096-5. Epub 2009 Feb 24. PubMed PMID: 19238312. 3: Tanaka-Amino K, Matsumoto K, Hatakeyama Y, Shima I, Takakura S, Muto S. ASP4,000, a novel, selective, dipeptidyl peptidase 4 inhibitor with antihyperglycemic activity. Eur J Pharmacol. 2008 Aug 20;590(1-3):444-9. doi: 10.1016/j.ejphar.2008.05.034. Epub 2008 Jun 24. PubMed PMID: 18582861.