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MedKoo Cat#: 573293 | Name: AS-1669058 free base

Description:

WARNING: This product is for research use only, not for human or veterinary use.

AS-1669058 free base is a G-protein-coupled receptor 119 (GPR119) agonist used to as new drug to treat type 2 diabetes.

Chemical Structure

AS-1669058 free base
CAS#1395553-31-7

Theoretical Analysis

MedKoo Cat#: 573293

Name: AS-1669058 free base

CAS#: 1395553-31-7

Chemical Formula: C18H15BrF2N4O

Exact Mass: 420.0397

Molecular Weight: 421.25

Elemental Analysis: C, 51.32; H, 3.59; Br, 18.97; F, 9.02; N, 13.30; O, 3.80

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
AS-1669058 free base
IUPAC/Chemical Name
3-(2-((2-(4-bromo-2,5-difluorophenyl)-6-methylpyrimidin-4-yl)amino)ethyl)pyridine 1-oxide
InChi Key
CCHGKGFZEORIJY-UHFFFAOYSA-N
InChi Code
1S/C18H15BrF2N4O/c1-11-7-17(22-5-4-12-3-2-6-25(26)10-12)24-18(23-11)13-8-16(21)14(19)9-15(13)20/h2-3,6-10H,4-5H2,1H3,(H,22,23,24)
SMILES Code
Cc1cc(nc(n1)c2cc(c(cc2F)Br)F)NCCc3ccc[n+](c3)[O-]
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 421.25 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Oshima H, Yoshida S, Ohishi T, Matsui T, Tanaka H, Yonetoku Y, Shibasaki M, Uchiyama Y. Novel GPR119 agonist AS1669058 potentiates insulin secretion from rat islets and has potent anti-diabetic effects in ICR and diabetic db/db mice. Life Sci. 2013 Feb 7;92(2):167-73. doi: 10.1016/j.lfs.2012.11.015. Epub 2012 Dec 13. PubMed PMID: 23246743.